{"created":"2023-05-15T16:34:25.366395+00:00","id":7014,"links":{},"metadata":{"_buckets":{"deposit":"1a4c7fe2-c8f9-4fcc-b764-c8bcaf9835f4"},"_deposit":{"created_by":2,"id":"7014","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"7014"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00007014","sets":["35:36"]},"author_link":["29705","29695","29696","29700","29703","29698","29694","29699","29706","29704","29697","29701","29702","29707"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"640","bibliographicPageStart":"635","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Virology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Dengue virus (DENV) infection remains a major public health burden worldwide. Soluble mediators may play a critical role in the pathogenesis of acute DENV infection. Galectin-9 (Gal-9) is a soluble β-galactoside-binding lectin, with multiple immunoregulatory and inflammatory properties. Objective: To investigate plasma Gal-9 levels as a biomarker for DENV infection. Study design: We enrolled 65 DENV infected patients during the 2010 epidemic in the Philippines and measured their plasma Gal-9 and cytokine/chemokine levels, DENV genotypes, and copy number during the critical and recovery phases of illness. Results: During the critical phase, Gal-9 levels were significantly higher in DENV infected patients compared to healthy or those with non-dengue febrile illness. The highest Gal-9 levels were observed in dengue hemorrhagic fever (DHF) patients (DHF: 2464. pg/ml; dengue fever patients (DF): 1407. pg/ml; non-dengue febrile illness: 616. pg/ml; healthy: 196. pg/ml). In the recovery phase, Gal-9 levels significantly declined from peak levels in DF and DHF patients. Gal-9 levels tracked viral load, and were associated with multiple cytokines and chemokines (IL-1α, IL-8, IP-10, and VEGF), including monocyte frequencies and hematologic variables of coagulation. Further discriminant analyses showed that eotaxin, Gal-9, IFN-α2, and MCP-1 could detect 92% of DHF and 79.3% of DF, specifically (P < 0.01). Conclusion: Gal-9 appears to track DENV inflammatory responses, and therefore, it could serve as an important novel biomarker of acute DENV infection and disease severity.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Clinical Virology, 58(4), pp.635-640; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jcv.2013.10.022","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 The Authors. Published by Elsevier B.V. All rights reserved."},{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13866532","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chagan-Yasutan, Haorile"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ndhlovu, Lishomwa C."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lacuesta, Talitha Lea"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Leano, Prisca Susan A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Niki, Toshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oguma, Shigeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morita, Kouichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chew, Glen. M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Barbour, Jason D."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Telan, Elizabeth Freda O."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirashima, Mitsuomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hattori, Toshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dimaano, Efren M."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"JCV58_635.pdf","filesize":[{"value":"663.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCV58_635.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/7014/files/JCV58_635.pdf"},"version_id":"d50fe0a8-d8b8-47ad-b3aa-8dde87a14d08"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Biomarker","subitem_subject_scheme":"Other"},{"subitem_subject":"Dengue fever","subitem_subject_scheme":"Other"},{"subitem_subject":"Dengue hemorrhagic fever","subitem_subject_scheme":"Other"},{"subitem_subject":"Dengue virus","subitem_subject_scheme":"Other"},{"subitem_subject":"Galectin-9","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-09"},"publish_date":"2014-01-09","publish_status":"0","recid":"7014","relation_version_is_last":true,"title":["Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:33:43.301053+00:00"}