{"created":"2023-05-15T16:34:25.707097+00:00","id":7022,"links":{},"metadata":{"_buckets":{"deposit":"ff9d3d38-9ed4-4682-8320-8587af25d79c"},"_deposit":{"created_by":2,"id":"7022","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"7022"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00007022","sets":["35:36"]},"author_link":["29756","29752","29753","29755","29754"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-10-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"4278","bibliographicPageStart":"4267","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Marine Drugs"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan induced apoptosis of an osteosarcoma cell line more efficiently than native fucoidan. The more potent effects of nanoparticle fucoidan, relative to native fucoidan, were confirmed in vivo using a xenograft osteosarcoma model. Caco-2 cell transport studies showed that permeation of nanoparticle fucoidan was higher than native fucoidan. The higher bioactivity and superior bioavailability of nanoparticle fucoidan could potentially be utilized to develop novel therapies for osteosarcoma.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Marine Drugs, 11(11), pp.4267-4278; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Multidisciplinary Digital Publishing Institute (MDPI)"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/md11114267","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"16603397","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kimura, Ryuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Rokkaku, Takayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeda, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Senba, Masachika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Naoki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"MarDru11_4267.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MarDru11_4267.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/7022/files/MarDru11_4267.pdf"},"version_id":"6220e43a-9b2c-4548-81e8-089649bb3b2d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Fucoidan","subitem_subject_scheme":"Other"},{"subitem_subject":"Lung metastasis","subitem_subject_scheme":"Other"},{"subitem_subject":"Nanoparticle","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteosarcoma","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-15"},"publish_date":"2014-01-15","publish_status":"0","recid":"7022","relation_version_is_last":true,"title":["Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:33:31.266046+00:00"}