@article{oai:nagasaki-u.repo.nii.ac.jp:00000708,
 author = {Umeda, Masataka and Origuchi, Tomoki and Kawashiri, Shin-ya and Koga, Tomohiro and Ichinose, Kunihiro and Furukawa, Kaori and Sato, Tomohito and Tsuji, Sousuke and Endo, Yushiro and Takatani, Ayuko and Shimizu, Toshimasa and Fukui, Shoichi and Iwamoto, Naoki and Igawa, Takashi and Tamai, Mami and Nakamura, Hideki and Kawakami, Atsushi},
 issue = {1},
 journal = {Scientific Reports},
 month = {Apr},
 note = {High serum concentrations of thymus and activation-regulated chemokine (TARC) are observed in allergic diseases such as atopic dermatitis and bronchial asthma. Frequent allergic symptoms have been reported in patients with IgG4-related disease (IgG4-RD). We investigated the pathogenic role of TARC as a biomarker in IgG4-RD patients. We evaluated the serum concentrations of TARC from 29 IgG4-RD patients, 28 primary Sjogren syndrome (pSS) patients, and 23 healthy controls (HCs) by enzyme-linked immunosorbent assay (ELISA). We analyzed the correlations between the TARC concentrations and the subjects’ clinical parameters. To investigate the biological effect of TARC on the pathogenesis of IgG4-RD, we evaluated the in vitro induction of plasmablasts from IgG4-RD patients by TARC. The serum concentrations of TARC in the IgG4-RD patients were significantly higher than those of the pSS patients and HCs. The serum TARC concentration of the IgG4-RD group was positively correlated with the IgG4-RD responder index (IgG4-RD RI) score and with the number of organs involved, but it was not correlated with the serum IgG4 level or eosinophil number in the IgG4-RD patients’ peripheral blood. The patients who had lung involvement had higher serum TARC concentrations. In vitro, TARC clearly induced the formation of plasmablasts from the IgG4-RD patients’ peripheral blood mononuclear cells. Collectively, our data suggest that a systemic increment of TARC may contribute to the development of IgG4-RD through an aberrant induction of plasmablasts., Scientific reports, 10(1), art.no.6010; 2020},
 title = {Thymus and Activation-regulated Chemokine as a Biomarker for IgG4-related Disease},
 volume = {10},
 year = {2020}
}