{"created":"2023-05-15T16:29:48.942043+00:00","id":709,"links":{},"metadata":{"_buckets":{"deposit":"1f39a934-7384-4970-a692-c41cb3d64c66"},"_deposit":{"created_by":2,"id":"709","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"709"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000709","sets":["10:11"]},"author_link":["3414","3420","3415","3416","3422","3418","3419","3421","3417","3413"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageStart":"2425","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Antxr1/Tem8 is highly expressed in tumor endothelial cells and is a receptor for anthrax toxin.\nMutation of Antxr1 causes GAPO syndrome, which is characterized by growth retardation, alopecia,\npseudo-anodontia, and optic atrophy. However, the mechanism underlying the growth retardation\nremains to be clarified. Runx2 is essential for osteoblast di erentiation and chondrocyte maturation and regulates chondrocyte proliferation through Ihh induction. In the search of Runx2 target genes in chondrocytes, we found that Antxr1 expression is upregulated by Runx2. Antxr1 was highly expressed in cartilaginous tissues and was directly regulated by Runx2. In skeletal development, the process of endochondral ossification proceeded similarly in wild-type and Antxr1?/? mice. However,the limbs of Antxr1?/? mice were shorter than those of wild-type mice from embryonic day 16.5 due to the reduced chondrocyte proliferation. Chondrocyte-specific Antxr1 transgenic mice exhibited shortened limbs, although the process of endochondral ossification proceeded as in wild-type mice.BrdU-uptake and apoptosis were both increased in chondrocytes, and the apoptosis-high regions were mineralized. These findings indicated that Antxr1, of which the expression is regulated by Runx2, plays an important role in chondrocyte proliferation and that overexpression of Antxr1 causes chondrocyte apoptosis accompanied by matrix mineralization.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"International journal of molecular sciences, 21(7), 2425; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/ijms21072425","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"16616596","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14220067","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Jiang, Qing"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Qin, Xin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Carolina Andrea"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komori, Hisato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamana, Kei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohba, Shinsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hojo, Hironori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Croix, Brad St."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawata-Matsuura, Viviane K. S."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komori, Toshihisa"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"IJMS21_2425.pdf","filesize":[{"value":"8.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"IJMS21_2425.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/709/files/IJMS21_2425.pdf"},"version_id":"30d0eb1f-0a3f-4409-9aea-6b431619954d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antxr1","subitem_subject_scheme":"Other"},{"subitem_subject":"Runx2","subitem_subject_scheme":"Other"},{"subitem_subject":"GAPO syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"chondrocyte proliferation","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-24"},"publish_date":"2020-04-24","publish_status":"0","recid":"709","relation_version_is_last":true,"title":["Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:13:22.657954+00:00"}