{"created":"2023-05-15T16:34:37.359987+00:00","id":7296,"links":{},"metadata":{"_buckets":{"deposit":"1152b212-5016-4ba3-8d47-7736d69c81a8"},"_deposit":{"created_by":2,"id":"7296","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"7296"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00007296","sets":["27:28"]},"author_link":["30645","30646","30647","30642","30643","30644"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"240","bibliographicPageStart":"233","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Dental Materials Journal"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study was designed to investigate the biological effects of fish collagen peptide (FCP) on human osteoblasts. Human osteoblasts were treated with 0.1% FCP, which was the optimal concentration confirmed by the increase in alkaline phosphatase activity. After one, three, five and seven days of culture, the number of FCP-treated cells increased significantly compared with untreated cells. In a real-time PCR analysis, the expression of osteocalcin, osteopontin, BMP-2 and integrin β3 mRNAs in FCP-treated cells showed increases compared with untreated cells after three days of culture. After seven days of culture, the expression levels of osteopontin and integrin β3 were still higher in the FCP-treated cells than in untreated cells. The production of osteocalcin, osteopontin and integrin β3 proteins in FCP-treated cells also showed increases after seven days of culture. Furthermore, FCP accelerated matrix mineralization in the cultures. The present study indicates the potential utility of FCP as a biomaterial.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Dental Materials Journal, 32(2), pp.233-240; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本歯科理工学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.4012/dmj.2012-188","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 The Japanese Society for Dental Materials and Devices"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02874547","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"18811361","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Japanese Society for Dental Materials and Devices"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamada, Shizuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshizawa, Yuu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakubo, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagiguchi, Kajiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Yoshihiko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"DMJ32_233.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DMJ32_233.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/7296/files/DMJ32_233.pdf"},"version_id":"4268453a-5ec0-4018-9242-d425069ab30c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alkaline phosphatase activity","subitem_subject_scheme":"Other"},{"subitem_subject":"Fish collagen peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoblast differentiation","subitem_subject_scheme":"Other"},{"subitem_subject":"Real-time PCR","subitem_subject_scheme":"Other"},{"subitem_subject":"Western blot analysis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Early gene and protein expression associated with osteoblast differentiation in response to fish collagen peptides powder","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Early gene and protein expression associated with osteoblast differentiation in response to fish collagen peptides powder"}]},"item_type_id":"2","owner":"2","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-06-05"},"publish_date":"2013-06-05","publish_status":"0","recid":"7296","relation_version_is_last":true,"title":["Early gene and protein expression associated with osteoblast differentiation in response to fish collagen peptides powder"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:27:27.951642+00:00"}