{"created":"2023-05-15T16:34:37.442633+00:00","id":7298,"links":{},"metadata":{"_buckets":{"deposit":"c83ea43f-928a-4d43-81be-a6b2112fef8f"},"_deposit":{"created_by":2,"id":"7298","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"7298"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00007298","sets":["35:36"]},"author_link":["30659","30661","30662","30664","30666","30663","30665","30660","30658"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"1572","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent studies show that some human malaria parasite species Plasmodium falciparum and P. vivax parasitize erythroblasts; however, the biological and clinical significance of this is unclear. To investigate further, we generated a rodent malaria parasite (P. yoelii 17XNL) expressing GFP-ovalbumin (OVA). Its infectivity to erythroblasts was confirmed, and parasitized erythroblasts were capable of initiating malaria infections. Experiments showed that MHC class I molecules were highly expressed on parasitized erythroblasts. As CD8+ T cells recognize MHC class I and peptide complexes on target cells, and are involved in protection or pathology against malaria, we examined whether erythroblasts are targeted by CD8+ T cells. Purified non-parasitized erythroblasts pulsed with OVA peptides were recognized by OVA-specific CD8 + T cells. Crucially, parasitized erythroblasts isolated from GFP-OVA-, but not GFP-infected-mice, activated OT-I CD8+ T cells, indicating that CD8+ T cells recognize parasitized erythroblasts in an antigen-specific manner.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific Reports, 3, 1572; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep01572","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"30658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishida, Hidekazu"}],"nameIdentifiers":[{"nameIdentifier":"30659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzue, Kazutomo"}],"nameIdentifiers":[{"nameIdentifier":"30660","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirai, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"30661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taniguchi, Tomoyo"}],"nameIdentifiers":[{"nameIdentifier":"30662","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Hiroko"}],"nameIdentifiers":[{"nameIdentifier":"30663","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Tomohisa"}],"nameIdentifiers":[{"nameIdentifier":"30664","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokawa, Chikako"}],"nameIdentifiers":[{"nameIdentifier":"30665","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisaeda, Hajime"}],"nameIdentifiers":[{"nameIdentifier":"30666","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"SciRep3_1572.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SciRep3_1572.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/7298/files/SciRep3_1572.pdf"},"version_id":"f42a9778-dc66-49be-8ee1-052c4b2ccbe7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"CD8+ T cell activation by murine erythroblasts infected with malaria parasites","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CD8+ T cell activation by murine erythroblasts infected with malaria parasites"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-06-05"},"publish_date":"2013-06-05","publish_status":"0","recid":"7298","relation_version_is_last":true,"title":["CD8+ T cell activation by murine erythroblasts infected with malaria parasites"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:27:26.369201+00:00"}