@article{oai:nagasaki-u.repo.nii.ac.jp:00007366,
 author = {Kondo, Takayuki and Asai, Masashi and Tsukita, Kayoko and Kutoku, Yumiko and Ohsawa, Yutaka and Sunada, Yoshihide and Imamura, Keiko and Egawa, Naohiro and Yahata, Naoki and Okita, Keisuke and Takahashi, Kazutoshi and Asaka, Isao and Aoi, Takashi and Watanabe, Akira and Watanabe, Kaori and Kadoya, Chie and Nakano, Rie and Watanabe, Dai and Maruyama, Kei and Hori, Osamu and Hibino, Satoshi and Choshi, Tominari and Nakahata, Tatsutoshi and Hioki, Hiroyuki and Kaneko, Takeshi and Naitoh, Motoko and Yoshikawa, Katsuhiro and Yamawaki, Satoko and Suzuki, Shigehiko and Hata, Ryuji and Ueno, Shu-ichi and Seki, Tsuneyoshi and Kobayashi, Kazuhiro and Toda, Tatsushi and Murakami, Kazuma and Irie, Kazuhiro and Klein, William L. and Mori, Hiroshi and Asada, Takashi and Takahashi, Ryosuke and Iwata, Nobuhisa and Yamanaka, Shinya and Inoue, Haruhisa},
 issue = {4},
 journal = {Cell Stem Cell},
 month = {Apr},
 note = {Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we generated induced pluripotent stem cells (iPSCs) from familial and sporadic AD patients and differentiated them into neural cells. Aβ oligomers accumulated in iPSC-derived neurons and astrocytes in cells from patients with a familial amyloid precursor protein (APP)-E693Δ mutation and sporadic AD, leading to endoplasmic reticulum (ER) and oxidative stress. The accumulated Aβ oligomers were not proteolytically resistant, and docosahexaenoic acid (DHA) treatment alleviated the stress responses in the AD neural cells. Differential manifestation of ER stress and DHA responsiveness may help explain variable clinical results obtained with the use of DHA treatment and suggests that DHA may in fact be effective for a subset of patients. It also illustrates how patient-specific iPSCs can be useful for analyzing AD pathogenesis and evaluating drugs., Cell Stem Cell, 12(4), pp.487-496; 2013},
 pages = {487--496},
 title = {Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness},
 volume = {12},
 year = {2013}
}