@article{oai:nagasaki-u.repo.nii.ac.jp:00000075,
 author = {Odatsu, Tetsurou and Kuroshima, Shinichiro and Sato, Mika and Takase, Kazuma and Valanezhad, Alireza and Naito, Mariko and Sawase, Takashi},
 issue = {6},
 journal = {Antibiotics},
 month = {Jun},
 note = {Peri-implantitis is an inflammatory disease with a relevant focus on the long-term success of dental implants and implant-supported
 prostheses. The present study focuses on the antibacterial effect of the silver nanoparticle and investigated the suppression 
of dental plaque adhesion on implant abutment and/or superstructure by micro-wave assistant nanosilver coating in vivo and in vitro.
 Nanosilver coating on pure titanium was prepared by microwave-assisted synthesis, and characterized by scanning electron microscopy 
and energy-dispersive X-ray spectroscopy. In vitro studies were conducted to analyze biocompatibility using MTS assay and fluorescence 
microscopy with human gingival fibroblasts to evaluate antibacterial activity. During the in vivo study,
 nanosilver coating was applied to the healing abutments, and the prevention of plaque accumulation 
on nanosilver coating was confirmed by a split-mouth randomized clinical trial. The aggregation of nano-sized particles was found 
on the titanium surface with an antibacterial effect. The coating had no cytotoxic effect on human gingival fibroblasts. 
The result of the clinical trial showed that the coating suppressed the dental plaque adhesion on the healing abutments. 
Nanosilver coating is a promising material with antibacterial properties and can be used for implant abutments and prostheses 
for preventing peri-implantitis., Antibiotics, 9(6), art.no.347; 2020},
 title = {Antibacterial Properties of Nano-Ag Coating on Healing Abutment: An In Vitro and Clinical Study},
 volume = {9},
 year = {2020}
}