{"created":"2023-05-15T16:34:48.657309+00:00","id":7561,"links":{},"metadata":{"_buckets":{"deposit":"dff5e770-7fc3-45da-9cb8-61317db2814c"},"_deposit":{"created_by":2,"id":"7561","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"7561"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00007561","sets":["29:30"]},"author_link":["31635","31634","31640","31636","31641","31637","31639","31638"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1644","bibliographicPageStart":"1636","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"DNA and Cell Biology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Several cell stresses induce nuclear factor-kappaB (NF-κB) activation, which include irradiation, oxidation, and UV. Interestingly, serum-starving stress-induced NF-κB activation in COS cells, but not in COS-A717 cells. COSA717 is a mutant cell line of COS cells that is defective of the NF-κB signaling pathway. We isolated genes with compensating activity for the NF-κB pathway and one gene encoded the G protein b2 (Gb2). Gb2 is one of the G rotein-coupled receptor signaling effectors. In COS-A717 cells, Gb2 expression is significantly reduced. In Gb2 cDNA-transfected COS-A717 cells, the NF-κB activity was increased along with the recovery of Gb2 expression. Furthermore, serum-starving stress induced the NF-κB activity in Gb2-transfected COS-A717 cells. Consistently, the serum-starved COS cells with siRNA-reduced Gb2 protein expression showed decreased NF-κB activity. These results indicate that Gb2 is required for starvation-induced NF-κB activation and constitutive NF-kB activity. We propose that serum contains some molecule(s) that strongly inhibits NF-κB activation mediated through Gβ2 signaling.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"DNA and Cell Biology, 31(11), pp.1636-1644; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Mary Ann Liebert Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1089/dna.2012.1666","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is a copy of an article published in the DNA and Cell Biology © 2012 Mary Ann Liebert, Inc.; DNA and Cell Biology is available online at: http://online.liebertpub.com."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10445498","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"15577430","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kohno, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Yoshinao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasui, Kiyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Haraguchi, Megumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shigematsu, Sayuri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chua, Koon Jiew"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuyama, Toshifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Hideki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"DCB31_1636.pdf","filesize":[{"value":"564.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DCB31_1636.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/7561/files/DCB31_1636.pdf"},"version_id":"1f0b9bf8-19b1-4282-9ff7-541ffb08d20a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Serum Starvation Activates NF-κB Through G Protein β2 Subunit-Mediated Signal","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Serum Starvation Activates NF-κB Through G Protein β2 Subunit-Mediated Signal"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-06-24"},"publish_date":"2013-06-24","publish_status":"0","recid":"7561","relation_version_is_last":true,"title":["Serum Starvation Activates NF-κB Through G Protein β2 Subunit-Mediated Signal"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:21:50.059968+00:00"}