{"created":"2023-05-15T16:35:00.751726+00:00","id":7842,"links":{},"metadata":{"_buckets":{"deposit":"70966582-83d3-4844-b59e-da99c36b08d7"},"_deposit":{"created_by":2,"id":"7842","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"7842"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00007842","sets":["35:36"]},"author_link":["32499","32500","32493","32497","32494","32495","32496","32501","32498"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"786","bibliographicPageStart":"783","bibliographicVolumeNumber":"74","bibliographic_titles":[{"bibliographic_title":"Human Immunology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We previously reported protective haplotype HLA-B*14:02-DRB1*01:02 against chronic Chagas disease in Bolivia. The V281L mutant allele of the 21-Hydroxylase gene, CYP21A2*15, is reported to be located in the Class III region of the Human leukocyte antigen region and linked to the haplotype HLA-B*14:02-DRB1*01:02. The mutant allele might play a primary role in the pathogenesis of chronic Chagas disease in the associated HLA region. We analyzed the frequency of this allele in the same subjects for the previous one. The statistical analysis showed a significant association of the CYP21A2*15 with resistance to severe chronic Chagas disease (OR=0.207273; Pv=0.0041). However, there is no significant tendency of the mutant gene contribution to the resistance after the elimination of the HLA-B*14:02-DRB1*01:02 linked mutants (OR=0.38; Pv=0.1533). Although the frequency of the CYP21A2*15 was small, we found no primary contribution of this mutation to the protection against chronic Chagas disease.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Human Immunology, 74(6), pp.783-786; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.humimm.2013.01.023","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 American Society for Histocompatibility and Immunogenetics"},{"subitem_rights":"NOTICE: this is the author’s version of a work that was accepted for publication in Human Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Human Immunology, 74, 6(2013)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01988859","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"del, Puerto  Florencia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kikuchi, Mihoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishizawa, Juan Eiki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Roca, Yelin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Avila, Cinthia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gianella, Alberto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lora, Javier"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gutierrez, Velarde  Freddy Udalrico"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirayama, Kenji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"HumImm74_783.pdf","filesize":[{"value":"393.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HumImm74_783.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/7842/files/HumImm74_783.pdf"},"version_id":"026b6b92-9e50-4e66-9392-fd0c83bf6cc6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Chagas disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Human Leukocyte Antigen","subitem_subject_scheme":"Other"},{"subitem_subject":"21-Hydroxylase","subitem_subject_scheme":"Other"},{"subitem_subject":"Haplotype","subitem_subject_scheme":"Other"},{"subitem_subject":"Linkage","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"21-Hydroxylase gene mutant allele CYP21A2∗15 strongly linked to the resistant HLA haplotype B∗14:02-DRB1∗01:02 in chronic Chagas disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"21-Hydroxylase gene mutant allele CYP21A2∗15 strongly linked to the resistant HLA haplotype B∗14:02-DRB1∗01:02 in chronic Chagas disease"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-10"},"publish_date":"2013-07-10","publish_status":"0","recid":"7842","relation_version_is_last":true,"title":["21-Hydroxylase gene mutant allele CYP21A2∗15 strongly linked to the resistant HLA haplotype B∗14:02-DRB1∗01:02 in chronic Chagas disease"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:16:52.250820+00:00"}