@article{oai:nagasaki-u.repo.nii.ac.jp:00000796, author = {Koto, Serina and Umeda, Masataka and Kawano, Hiroaki and Endo, Yushiro and Shimizu, Toshimasa and Koga, Tomohiro and Ichinose, Kunihiro and Nakamura, Hideki and Mukaino, Akihiro and Higuchi, Osamu and Nakane, Shunya and Kawakami, Atsushi}, issue = {8}, journal = {Internal Medicine}, month = {Apr}, note = {A 58-year-old Japanese woman with herpes zoster developed Behcet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders., Internal Medicine, 59(8), pp.1099-1104; 2020}, pages = {1099--1104}, title = {Behcet's Disease with Severe Autonomic Disorders Developing after Herpes Zoster}, volume = {59}, year = {2020} }