{"created":"2023-05-15T16:29:22.002194+00:00","id":82,"links":{},"metadata":{"_buckets":{"deposit":"dc357679-32e7-44a1-9a52-a93f73fe316b"},"_deposit":{"created_by":2,"id":"82","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"82"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000082","sets":["35:36"]},"author_link":["411","412","416","408","410","413","415","409","414"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageStart":"101544","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"iScience"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Entamoeba histolytica, a protozoan parasite in the lumen of the human large intestine, occasionally spreads to the liver and induces \namebic liver abscesses (ALAs). Upon infection with E. histolytica, high levels of type 2 cytokines are induced in the liver early \nafter infection. However, the sources and functions of these initial type 2 cytokines in ALA formation remain unclear. In this study, \nwe examined the roles of group 2 innate lymphoid cells (ILC2s) in ALA formation. Hepatic ILC2 numbers were significantly increased and they produced robust levels of IL-5. The in vivo transfer of ILC2s into Rag2?/?common γ chain (γc)?/? KO mice aggravated ALA formation accompanied by eosinophilia and neutrophilia. Furthermore, IL-33-deficient mice and IL-5-neutralized mice had less ALA formations. These results suggest that ILC2s contribute to exacerbating the pathogenesis of ALA by producing early type 2 cytokines \nand promoting the accumulation of eosinophils and neutrophils in the liver.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"iScience, 23 (9), art.no.101544; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Cell Press"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.isci.2020.101544","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"25890042","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakamura, Risa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshizawa, Akihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriyasu, Taeko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Deloer, Sharmina"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Senba, Masachika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kikuchi, Mihoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koyasu, Shigeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moro, Kazuyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamano, Shinjiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-16"}],"displaytype":"detail","filename":"iSci23_101544.pdf","filesize":[{"value":"5.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iSci23_101544.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/82/files/iSci23_101544.pdf"},"version_id":"54660c87-ef9f-4aca-a049-138d5d3af0d7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Immunology","subitem_subject_scheme":"Other"},{"subitem_subject":"Microbiology","subitem_subject_scheme":"Other"},{"subitem_subject":"Microbiology Parasite","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-06"},"publish_date":"2020-10-06","publish_status":"0","recid":"82","relation_version_is_last":true,"title":["Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:21:48.528080+00:00"}