{"created":"2023-05-15T16:35:20.936050+00:00","id":8236,"links":{},"metadata":{"_buckets":{"deposit":"f7f703df-12a1-436c-b25f-fffedfeffe38"},"_deposit":{"created_by":2,"id":"8236","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"8236"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00008236","sets":["35:36"]},"author_link":["33648","33649","33647"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1803","bibliographicPageStart":"1800","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"Respiratory Medicine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia. The pathogenicity of IPF has been widely investigated but still remains to be clarified. Efferocytosis, the specialized recognition and ingestion of apoptotic cells by phagocytes, is essential for the resolution of inflammation in the lungs and repair of injured tissues. Impaired efferocytosis contributes to the pathogenesis of chronic lung diseases such as emphysema and cystic fibrosis. We hypothesized that efferocytosis would also be reduced in alveolar macrophages isolated from subjects with IPF. Methods: Efferocytosis, was evaluated using Wright-Giemsa stained cell preparations isolated from the bronchoalveolar lavage (BAL) fluid of patients with IPF (n = 5), nonspecific interstitial pneumonitis (n = 6), cryptogenic organizing pneumonia (n = 4) and eosinophilic pneumonia (EP) (n = 5). Results: Uningested apoptotic cells were significantly higher in BAL fluid from patients with IPF compared to other forms of interstitial lung disease. Macrophages isolated from patients with eosinophilic pneumonia had significantly fewer phagocytic ingestions than macrophages from the other three groups. Conclusion: Efferocytosis by alveolar macrophages was significantly lower in subjects with IPF compared to subjects with other interstitial pneumonia. Dysregulated efferocytosis may contribute to the pathogenesis of IPF.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Respiratory Medicine, 106(12), pp.1800-1803; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"W.B. Saunders Ltd"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.rmed.2012.08.020","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Elsevier Ltd. All rights reserved."},{"subitem_rights":"NOTICE: this is the author’s version of a work that was accepted for publication in Respiratory Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Respiratory Medicine, 106, 12(2012)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09546111","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Morimoto, Konosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Janssen, William J."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Terada, Mayumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"ResMed106_1800.pdf","filesize":[{"value":"377.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ResMed106_1800.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/8236/files/ResMed106_1800.pdf"},"version_id":"2ab03581-47d0-44c3-aeb2-399125c08410"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"BAL","subitem_subject_scheme":"Other"},{"subitem_subject":"Efferocytosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Idiopathic interstitial pneumonia","subitem_subject_scheme":"Other"},{"subitem_subject":"Idiopathic pulmonary fibrosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Defective efferocytosis by alveolar macrophages in IPF patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Defective efferocytosis by alveolar macrophages in IPF patients"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-03-12"},"publish_date":"2013-03-12","publish_status":"0","recid":"8236","relation_version_is_last":true,"title":["Defective efferocytosis by alveolar macrophages in IPF patients"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:09:39.466254+00:00"}