@article{oai:nagasaki-u.repo.nii.ac.jp:00008262,
 author = {Nakamoto, Morito and Hirose, Makoto and Kawakatsu, Miho and Nakayama, Toshiyuki and Urata, Yoshishige and Kamata, Kensaku and Kaminogo, Makio and Li, Tao-Sheng and Nagata, Izumi},
 issue = {16-17},
 journal = {Clinical Biochemistry},
 month = {Nov},
 note = {Objectives: As oxidative stress is known to be associated with the development of atherosclerosis, we investigated whether the serum S-glutathionylated proteins were increased in patients with carotid artery stenosis (CS). Design and methods: Fifty-four patients with CS and 20 age-matched non-CS patients were involved in this study. S-glutathionylated proteins in serum were examined by immunoblot analysis using an antibody against S-glutathionylated bovine serum albumin. Results: The antibody against S-glutathionylated bovine serum albumin was confirmed to specifically recognize the serum S-glutathionylated proteins in patient samples. The S-glutathionylated proteins in serum were significantly increased in the patients with CS (p<. 0.01) compared to the non-CS patients, and the increase did not depend on the stage of CS. Logistic regression analysis revealed that the serum levels of S-glutathionylated proteins were associated with the development of CS (p<. 0.01). Conclusions: Oxidative stress likely contributes to the development of CS, and serum S-glutathionylated proteins may be a potential biomarker of CS., Clinical Biochemistry, 45(16-17), pp.1331-1335; 2012},
 pages = {1331--1335},
 title = {Serum S-glutathionylated proteins as a potential biomarker of carotid artery stenosis},
 volume = {45},
 year = {2012}
}