{"created":"2023-05-15T16:35:23.634994+00:00","id":8277,"links":{},"metadata":{"_buckets":{"deposit":"db66e7eb-8131-45fc-88bb-f68f98ff15ed"},"_deposit":{"created_by":2,"id":"8277","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"8277"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00008277","sets":["25:26"]},"author_link":["33860","33861","33859","33863","33865","33866","33864","33867","33862"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-11-14","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"e48052","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Delayed wound healing is a serious clinical problem in patients after surgery. A recent study has demonstrated that bone marrow-derived c-kit-positive (c-kit+) cells play important roles in repairing and regenerating various tissues and organs. To examine the hypothesis that surgical injury induces the mobilization and recruitment of c-kit+ cells to accelerate wound healing. Mice were subjected to a left pneumonectomy. The mobilization of c-kit+ cells was monitored after surgery. Using green fluorescent protein (GFP+) bone marrow-transplanted chimera mice, we investigated further whether the mobilized c-kit+ cells were recruited to effect wound healing in a skin puncture model. The group with left pneumonectomies increased the c-kit+ and CD34+ stem cells in peripheral blood 24 h after surgery. At 3 days after surgery, the skin wound size was observed to be significantly smaller, and the number of bone marrow-derived GFP+ cells and GFP+/c-kit+ cells in the wound tissue was significantly greater in mice that had received pneumonectomies, as compared with those that had received a sham operation. Furthermore, some of these GFP+ cells were positively expressed specific markers of macrophages (F4/80), endothelial cells (CD31), and myofibroblasts (αSMA). The administration of AMD3100, an antagonist of a stromal-cell derived factor (SDF)-1/CXCR4 signaling pathway, reduced the number of GFP+ cells in wound tissue and completely negated the accelerated wound healing. Surgical injury induces the mobilization and recruitment of c-kit+ cells to contribute to wound healing. Regulating c-kit+ cells may provide a new approach that accelerates wound healing after surgery.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLoS ONE, 7(11), e48052; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0048052","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Takemoto et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takemoto, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Tao-Sheng"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Masayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohshima, Mako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurazumi, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueda, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Enoki, Tadahiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murata, Tomoaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamano, Kimikazu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"PLoS7_48052.pdf","filesize":[{"value":"819.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PLoS7_48052.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/8277/files/PLoS7_48052.pdf"},"version_id":"b7b67c54-d945-4309-9425-133872c2a1f0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Mobilization and Recruitment of C-Kit+ Cells Contribute to Wound Healing after Surgery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Mobilization and Recruitment of C-Kit+ Cells Contribute to Wound Healing after Surgery"}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-03-18"},"publish_date":"2013-03-18","publish_status":"0","recid":"8277","relation_version_is_last":true,"title":["The Mobilization and Recruitment of C-Kit+ Cells Contribute to Wound Healing after Surgery"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:08:47.752169+00:00"}