{"created":"2023-05-15T16:35:27.636181+00:00","id":8359,"links":{},"metadata":{"_buckets":{"deposit":"399a5e28-5766-4087-83cb-f008bf85e658"},"_deposit":{"created_by":2,"id":"8359","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"8359"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00008359","sets":["29:30"]},"author_link":["34082","34084","34083"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"446","bibliographicPageStart":"443","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Prion"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Despite recent progress in the understanding of prion diseases, little is known about the host-defense mechanisms against prion. Although it has long been thought that type I interferon (IFN-I) has no protective effect on prion infection, certain key molecules in innate immunity such as toll-like receptor (TLR) 4 seemed to be involved in the host response. For this reason we decided to focus on TLRs and investigate the role of a transcription factor, interferon regulatory factor 3 (IRF3), because the absence of MyD88, a major adaptor signaling molecule of TLRs, has no effect on the survival of prion infected mice. Intriguingly, survival periods of prion inoculated IRF3-knockout mice became significantly shorter than those of wildtype mice. In addition, IRF3 stimulation inhibited PrPSc replication in prion persistently- infected cells, and a de novo prion infection assay revealed that IRF3-overexpression could make host cells resistant to prion infection. Our work suggests that IRF3 may play a key role in innate immune responses against invasion of prion pathogens. Activated IRF3 could upregulate several anti-pathogen factors, including IFN-I, and induce sequential responses. Although the mechanism for the anti-prion effects mediated by IRF3 has yet to be clarified, certain interferon responsive genes might be involved in the anti-prion host-defense mechanism.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Prion, 6(5), pp.443-446; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Landes Bioscience"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.4161/pri.22579","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Landes Bioscience."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"19336896","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishibashi, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Atarashi, Ryuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishida, Noriyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"Prion6_443.pdf","filesize":[{"value":"310.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Prion6_443.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/8359/files/Prion6_443.pdf"},"version_id":"6d8e7ada-e356-48b1-aabc-4f9972f9beb2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Host defense","subitem_subject_scheme":"Other"},{"subitem_subject":"Innate immunity","subitem_subject_scheme":"Other"},{"subitem_subject":"Interferon regulatory factor 3 (IRF3)","subitem_subject_scheme":"Other"},{"subitem_subject":"Prion","subitem_subject_scheme":"Other"},{"subitem_subject":"Type I interferon (IFN)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protective role of MyD88-independent innate immune responses against prion infection","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protective role of MyD88-independent innate immune responses against prion infection"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-12-01"},"publish_date":"2013-12-01","publish_status":"0","recid":"8359","relation_version_is_last":true,"title":["Protective role of MyD88-independent innate immune responses against prion infection"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:07:04.721039+00:00"}