{"created":"2023-05-15T16:29:54.535058+00:00","id":840,"links":{},"metadata":{"_buckets":{"deposit":"5b6d4bf5-eaa8-4c8a-9556-0e7ae7b63e01"},"_deposit":{"created_by":2,"id":"840","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"840"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000840","sets":["10:11"]},"author_link":["3978","3971","3979","3977","3973","3975","3980","3972","3974","3976"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"144","bibliographicPageStart":"135","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Oncology Letters"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"c-Met is a receptor tyrosine kinase that binds a specific ligand, namely hepatocyte growth factor (HGF). The HGF/c-Met system is important for malignant aggressiveness in various types of cancer, including bladder cancer (BC). However, although phosphorylation is the essential step required for biological activation of c-Met, pathological roles of phosphorylated c-Met at the clinical and molecular levels in patients with BC are not fully understood. In the present study, the expression levels of c-Met and the phosphorylation of two of its tyrosine residues (pY1234/pY1235 and pY1349) were immunohistochemically examined in 185 BC tissues. The associations between these expression levels and cancer cell invasion, metastasis, and cyclooxygenase-2 (COX-2), heme oxygenase-1 (HO-1), VEGF-A and programmed death ligand 1 (PD-L1) levels were investigated. c-Met was associated with muscle invasion (P=0.021), as well as the expression levels of HO-1 (P=0.028) and PD-L1 (P<0.001), whereas pY1349 c-Met was associated with muscle invasion (P=0.003), metastasis (P=0.025), and COX-2 (P=0.017), HO-1 (P=0.031) and PD-L1 (P=0.001) expression. By contrast, pY1234/1235 c-Met was associated with muscle invasion and metastasis (P=0.006 and P=0.012, respectively), but not with the panel of cancer-associated molecules. Furthermore, COX-2 and PD-L1 expression were associated with muscle invasion and metastasis, respectively (P=0.045 and P=0.036, respectively). Hence, c-Met serves important roles in muscle invasion by regulating HO-1 and PD-L1, whereas its phosphorylation at Y1349 is associated with muscle invasion and metastasis via the regulation of COX-2, HO-1 and PD-L1 in patients with BC. Furthermore, phosphorylation at Y1234/1235 may lead to muscle invasion and metastasis via alternate mechanisms associated with c-Met and pY1349 c-Met.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Oncology Letters, 20(1), pp.135-144; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/ol.2020.11540","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c Mukae et al. This is an open access article distributed under the terms of Creative Commons Attribution License."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"17921074","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"17921082","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mukae, Yuta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyata, Yasuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Yuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Araki, Kyohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Otsubo, Asato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yuno, Tsutomu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsunari, Kensuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohba, Kojiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Hideki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"OncLet20_135.pdf","filesize":[{"value":"480.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"OncLet20_135.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/840/files/OncLet20_135.pdf"},"version_id":"a2841583-fa19-4aa7-a8ff-056484bc2ec2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"c?Met","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphorylation","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclooxygenase?2","subitem_subject_scheme":"Other"},{"subitem_subject":"heme oxygenase?1","subitem_subject_scheme":"Other"},{"subitem_subject":"vascular endothelial growth factor?A","subitem_subject_scheme":"Other"},{"subitem_subject":"programmed death ligand 1","subitem_subject_scheme":"Other"},{"subitem_subject":"bladder cancer","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pathological roles of c-Met in bladder cancer: Association with cyclooxygenase-2, heme oxygenase-1, vascular endothelial growth factor-A and programmed death ligand 1","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pathological roles of c-Met in bladder cancer: Association with cyclooxygenase-2, heme oxygenase-1, vascular endothelial growth factor-A and programmed death ligand 1"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-06-10"},"publish_date":"2020-06-10","publish_status":"0","recid":"840","relation_version_is_last":true,"title":["Pathological roles of c-Met in bladder cancer: Association with cyclooxygenase-2, heme oxygenase-1, vascular endothelial growth factor-A and programmed death ligand 1"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:12:24.431904+00:00"}