{"created":"2023-05-15T16:35:51.871182+00:00","id":8869,"links":{},"metadata":{"_buckets":{"deposit":"0b3892bc-5c67-4966-b691-3c6d77d59f5e"},"_deposit":{"created_by":2,"id":"8869","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"8869"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00008869","sets":["35:36"]},"author_link":["35726","35709","35710","35717","35712","35724","35714","35727","35722","35718","35728","35715","35719","35720","35721","35723","35711","35725","35713","35716"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"e55227","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aims: Familial Mediterranean Fever (FMF) has traditionally been considered to be an autosomal-recessive disease, however, it has been observed that substantial numbers of patients with FMF possess only 1 demonstrable MEFV mutation. The clinical profile of familial Mediterranean fever (FMF) may be influenced by MEFV allelic heterogeneity and other genetic and/or environmental factors. Methodology/Principal Findings: In view of the inflammatory nature of FMF, we investigated whether serum amyloid A (SAA) and interleukin-1 beta (IL-1β) gene polymorphisms may affect the susceptibility of Japanese patients with FMF. The genotypes of the -13C/T SNP in the 5′-flanking region of the SAA1 gene and the two SNPs within exon 3 of SAA1 (2995C/T and 3010C/T polymorphisms) were determined in 83 Japanese patients with FMF and 200 healthy controls. The same samples were genotyped for IL-1β-511 (C/T) and IL-1 receptor antagonist (IL-1Ra) variable number of tandem repeat (VNTR) polymorphisms. There were no significant differences between FMF patients and healthy subjects in the genotypic distribution of IL-1β -511 (C/T), IL-1Ra VNTR and SAA2 polymorphisms. The frequencies of SAA1.1 allele were significantly lower (21.7% versus 34.0%), and inversely the frequencies of SAA1.3 allele were higher (48.8% versus 37.5%) in FMF patients compared with healthy subjects. The frequency of -13T alleles, associated with the SAA1.3 allele in the Japanese population, was significantly higher (56.0% versus 41.0%, p = 0.001) in FMF patients compared with healthy subjects. Conclusions/Significance: Our data indicate that SAA1 gene polymorphisms, consisting of -13T/C SNP in the 5′-flanking region and SNPs within exon 3 (2995C/T and 3010C/T polymorphisms) of SAA1 gene, are associated with susceptibility to FMF in the Japanese population.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLoS ONE, 8(2), e55227; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0055227","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 Migita et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Migita, Kiyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Agematsu, Kazunaga"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masumoto, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ida, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honda, Seiyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jiuchi, Yuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izumi, Yasumori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Yumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uehara, Ritei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Yoshikazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koga, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Munetoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujieda, Yuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nonaka, Fumiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Katsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furukawa, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Tadashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasunami, Michio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"PLoS8_55227.pdf","filesize":[{"value":"160.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PLoS8_55227.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/8869/files/PLoS8_55227.pdf"},"version_id":"7dc55a43-f0d5-4e7c-9fe0-fd8ef789335f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Contribution of SAA1 Polymorphisms to Familial Mediterranean Fever Susceptibility in the Japanese Population","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Contribution of SAA1 Polymorphisms to Familial Mediterranean Fever Susceptibility in the Japanese Population"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-05-09"},"publish_date":"2013-05-09","publish_status":"0","recid":"8869","relation_version_is_last":true,"title":["The Contribution of SAA1 Polymorphisms to Familial Mediterranean Fever Susceptibility in the Japanese Population"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:57:08.598111+00:00"}