@article{oai:nagasaki-u.repo.nii.ac.jp:00008960,
 author = {Takagi, Katsunori and Araki, Masato and Fukuoka, Hidetoshi and Takeshita, Hiroaki and Hidaka, Shigekazu and Nanashima, Atsushi and Sawai, Terumitsu and Nagayasu, Takeshi and Hyon, Suong-Hyu and Nakajima, Naoki},
 issue = {4},
 journal = {International Journal of Medical Sciences},
 month = {Mar},
 note = {Background: Although laparoscopic surgery has decreased postoperative adhesions, complications induced by adhesions are still of great concern. The aim of this study was to investigate the anti-adhesive effects of a novel powdered anti-adhesion material that can be applied during laparoscopic surgery in comparison with other anti-adhesion materials. Methods: Our novel powdered anti-adhesion material is composed of aldehyde dextran and ε-poly(L-lysine). In 40 male rats, a 2.5×2.0-cm abdominal wall resection and cecum abrasion were performed. The rats were randomized into four groups based on the anti-adhesion treatments: normal saline; Seprafilm® Interceed® and novel powdered anti-adhesion material. The animals were euthanized on days 7 and 28 to evaluate the adhesion severity, area of adhesion formation, gross appearance, and pathological changes. Results: The adhesion severities on both days 7 and 28 were significantly lower for all anti-adhesion material groups compared with the normal saline group (p<0.05). Pathologically, all groups showed inflammatory cell infiltration on day 7 and complete regeneration of the peritoneum on day 28. Conclusions: Our novel powdered anti-adhesion material was found to be effective for reducing postoperative intra-abdominal adhesions and showed equivalent efficacy to commercial anti-adhesion materials., International Journal of Medical Sciences, 10(4), pp.467-474; 2013},
 pages = {467--474},
 title = {Novel Powdered Anti-adhesion Material: Preventing Postoperative Intra-abdominal Adhesions in a Rat Model},
 volume = {10},
 year = {2013}
}