@article{oai:nagasaki-u.repo.nii.ac.jp:00008979,
 author = {Okamoto, Masaki and Fujimoto, Kiminori and Nakamura, Masayuki and Yoshida, Tsukasa and Idemoto, Akiko and Kitasato, Yasuhiko and Kawayama, Tomotaka and Fukuoka, Junya and Ichiki, Masao and Hoshino, Tomoaki},
 issue = {5},
 journal = {Internal Medicine},
 month = {Mar},
 note = {A 49-year-old man with dyspnea was found to have reticular opacities and ground-glass attenuation with traction bronchiectasis or bronchiolectasis on computed tomography. The patient met the criteria for lungdominant connective tissue disease (LD-CTD) and histopathologically exhibited a chronic fibrotic interstitial pneumonia illustrating framework of a usual interstitial pneumonia-like pattern. Due to worsening of the disease, therapy was initiated with corticosteroids in combination with cyclosporine A. However, treatment with these drugs was ineffective. Pirfenidone and intravenous cyclophosphamide therapy also proved ineffective. The cyclosporine A was therefore switched to tacrolimus, and the patient's disease improved, allowing for a reduction in the dose of the corticosteroids. Our experience in this case suggests that treatment with tacrolimus might be useful for treating refractory LD-CTD even when histopathologically chronic fibrotic interstitial pneumonia is evident., Internal Medicine, 52(5), pp.605-609; 2013},
 pages = {605--609},
 title = {Successful Treatment with Tacrolimus in a Case of Lung-dominant Connective Tissue Disease},
 volume = {52},
 year = {2013}
}