{"created":"2023-05-15T16:36:16.914502+00:00","id":9295,"links":{},"metadata":{"_buckets":{"deposit":"9d712237-3c87-42c1-8c82-334fc37719ae"},"_deposit":{"created_by":2,"id":"9295","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"9295"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00009295","sets":["27:28"]},"author_link":["37337","37342","37338","37341","37343","37340","37339"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"573","bibliographicPageStart":"563","bibliographicVolumeNumber":"141","bibliographic_titles":[{"bibliographic_title":"American Journal of Orthodontics and Dentofacial Orthopedics"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: The effect of zoledronic acid, a potent and novel bisphosphonate, on tooth movement and orthodontically induced root resorption in osteoporotic animals systemically treated with zoledronic acid as similarly used in postmenopausal patients has not been elucidated. Therefore, this study was undertaken. Methods: Fifteen 10-week-old female Wistar rats were divided into 3 groups: ovariectomy, ovariectomy + zoledronic acid, and control. Only the ovariectomy and ovariectomy + zoledronic acid groups underwent ovariectomies. Two weeks after the ovariectomy, zoledronic acid was administered only to the ovariectomy + zoledronic acid group. Four weeks after the ovariectomy, 25-g nickel-titanium closed-coil springs were applied to observe tooth movement and orthodontically induced root resorption. Results: There were significant differences in the amounts of tooth movement and orthodontically induced root resorption between the ovariectomy and the control groups, and also between the ovariectomy and the ovariectomy + zoledronic acid groups. There was no statistically significant difference in tooth movement and orthodontically induced root resorption between the ovariectomy + zoledronic acid and the control groups. Zoledronic acid inhibited significantly more tooth movement and significantly reduced the severity of orthodontically induced root resorption in the ovariectomized rats. The ovariectomy + zoledronic acid group showed almost the same results as did the control group in both tooth movement and orthodontically induced root resorption. Conclusions: Zoledronic acid inhibits excessive orthodontic tooth movement and also reduces the risk of severe orthodontically induced root resorption in ovariectomized rats.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"American Journal of Orthodontics and Dentofacial Orthopedics, 141(5), pp.563-573; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Mosby Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ajodo.2011.11.016","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved."},{"subitem_rights":"NOTICE: this is the author’s version of a work that was accepted for publication in American Journal of Orthodontics and Dentofacial Orthopedics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in American Journal of Orthodontics and Dentofacial Orthopedics, 141, 5(2012)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"08895406","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sirisoontorn, Irin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hotokezaka, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashimoto, Megumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gonzales, Carmen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Luppanapornlarp, Suwannee"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Darendeliler, M. Ali"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Noriaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"AJODO141_563.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AJODO141_563.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/9295/files/AJODO141_563.pdf"},"version_id":"ee00c934-f35e-4b42-963a-771625d96347"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bisphosphonic acid derivative","subitem_subject_scheme":"Other"},{"subitem_subject":"bone density conservation agent","subitem_subject_scheme":"Other"},{"subitem_subject":"imidazole derivative","subitem_subject_scheme":"Other"},{"subitem_subject":"zoledronic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"animal","subitem_subject_scheme":"Other"},{"subitem_subject":"article","subitem_subject_scheme":"Other"},{"subitem_subject":"comparative study","subitem_subject_scheme":"Other"},{"subitem_subject":"disease model","subitem_subject_scheme":"Other"},{"subitem_subject":"female","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoporosis","subitem_subject_scheme":"Other"},{"subitem_subject":"periodontal disease","subitem_subject_scheme":"Other"},{"subitem_subject":"postmenopause","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_scheme":"Other"},{"subitem_subject":"tooth disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Wistar rat","subitem_subject_scheme":"Other"},{"subitem_subject":"Diphosphonates","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoporosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Root Resorption","subitem_subject_scheme":"Other"},{"subitem_subject":"Tooth Movement","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid"}]},"item_type_id":"2","owner":"2","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-29"},"publish_date":"2012-11-29","publish_status":"0","recid":"9295","relation_version_is_last":true,"title":["Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:49:24.235946+00:00"}