{"created":"2023-05-15T16:36:18.922971+00:00","id":9338,"links":{},"metadata":{"_buckets":{"deposit":"338ad0c9-fc28-4eac-b071-bd977cf578bf"},"_deposit":{"created_by":2,"id":"9338","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"9338"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00009338","sets":["10:11"]},"author_link":["37594","37585","37600","37588","37597","37598","37592","37596","37593","37589","37587","37591","37601","37604","37602","37595","37603","37590","37599","37586"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"e72","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"Blood Cancer Journal"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated prognostic factors for the clinical outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) following imatinib-based therapy. Among 100 adult patients who were prospectively enrolled in the JALSG Ph+ALL202 study, 97 patients obtained complete remission (CR) by imatinib-combined chemotherapy, among whom 60 underwent allo-HSCT in their first CR. The probabilities of overall survival (OS) and disease-free survival (DFS) at 3 years after HSCT were 64% (95% CI, 49–76) and 58% (95% CI, 43–70), respectively. Prognostic factor analysis revealed that the major BCR–ABL transcript was the only unfavorable predictor for OS and DFS after HSCT by both univariate (HR, 3.67 (95% CI 1.49–9.08); P=0.005 and HR, 6.25 (95% CI, 1.88–20.8); P=0.003, respectively) and multivariate analyses (HR, 3.20 (95% CI, 1.21–8.50); P=0.019 and HR, 6.92 (95% CI, 2.09–22.9); P=0.002, respectively). Minimal residual disease status at the time of HSCT had a significant influence on relapse rate (P=0.015). Further study of the BCR–ABL subtype for the clinical impact on outcome of allo-HSCT in Ph+ALL is warranted.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Blood Cancer Journal, 2(5), e72; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Macmillan Publishers Limited"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/bcj.2012.18","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Macmillan Publishers Limited All rights reserved 2044-5385/12"},{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20445385","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mizuta, Shuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Keitaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Tomoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yujiri, Toshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hatta, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Yukihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueda, Yasunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanamori, Heiwa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Usui, Noriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akiyama, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takada, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokota, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takatsuka, Yoshifusa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamaki, Sigehisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imai, Kiyotoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriuchi, Yukiyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohtake, Shigeki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohnishi, Kazunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naoe, Tomoki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"BCJ2_72.pdf","filesize":[{"value":"349.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BCJ2_72.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/9338/files/BCJ2_72.pdf"},"version_id":"9d329cef-8bfb-4b77-b519-096dc931c218"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"philadelphia chromosome-positive acute lymphoblastic leukemia","subitem_subject_scheme":"Other"},{"subitem_subject":"imatinib","subitem_subject_scheme":"Other"},{"subitem_subject":"allogeneic hematopoietic stem cell transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"prognostic factor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prognostic factors influencing clinical outcome of allogeneic hematopoietic stem cell transplantation following imatinib-based therapy in BCR–ABL-positive ALL","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prognostic factors influencing clinical outcome of allogeneic hematopoietic stem cell transplantation following imatinib-based therapy in BCR–ABL-positive ALL"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-12-04"},"publish_date":"2012-12-04","publish_status":"0","recid":"9338","relation_version_is_last":true,"title":["Prognostic factors influencing clinical outcome of allogeneic hematopoietic stem cell transplantation following imatinib-based therapy in BCR–ABL-positive ALL"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:48:25.825606+00:00"}