{"created":"2023-05-15T16:36:19.120618+00:00","id":9341,"links":{},"metadata":{"_buckets":{"deposit":"fa2e171b-e9de-426f-8828-d42b71bf8133"},"_deposit":{"created_by":2,"id":"9341","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"9341"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00009341","sets":["35:36"]},"author_link":["37609","37608"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-09-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4SUPPLEMENT","bibliographicPageEnd":"S62","bibliographicPageStart":"S53","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Tropical Medicine and Health"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Huge emphasis has been placed oen the role of the adaptive immune system in dengue pathogenesis. Yet there is increasing evidence for the importance of the innate immune system in regulating dengue infection and possibly influencing the disease. This review focuses on the interplay between the innate immune system and dengue and highlights the role of soluble immunological mediators. Type I and type II interferons of the innate immune system demonstrate non-overlapping roles in dengue infection. Furthermore, while some IFN responses to dengue are protective, others may exert disease-related effects on the host. But aside from interferons, a number of cytokines have also been implicated in dengue pathogenesis. Our expanding knowledge of cytokines indicates that these soluble mediators act upon a complicated network of events to provoke the disease. This cytokine storm is generally attributed to massive T cell activation as an outcome of secondary infection. However, there is reason to believe that innate immune response-derived cytokines also have contributory effects, especially in the context of severe cases of primary dengue infection. Another less popular but interesting perspective on dengue pathogenesis is the effect of mosquito feeding on host immune responses and viral infection. Various studies have shown that soluble factors from vector saliva have the capacity to alter immune reactions and thereby influence pathogen transmission and establishment. Hence, modulation of the innate immune system at various levels of infection is a critical component of dengue disease. In the absence of an approved drug or vaccine for dengue, soluble mediators of the innate immune system could be a strategic foothold for developing anti-viral therapeutics and improving clinical management.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Tropical Medicine and Health, 39(4SUPPLEMENT), pp.S53-S62; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本熱帯医学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2149/tmh.2011-S06","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2011 by The Japanese Society of Tropical Medicine."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13488945","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13494147","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"The Japanese Society of Tropical Medicine"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Espada-Murao, Lyre Anni"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morita, Kouichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"TMH39_S53.pdf","filesize":[{"value":"215.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"TMH39_S53.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/9341/files/TMH39_S53.pdf"},"version_id":"05a438cd-82e6-4cf7-84f9-e7ef0b15b030"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon","subitem_subject_scheme":"Other"},{"subitem_subject":"recombinant alpha2a interferon","subitem_subject_scheme":"Other"},{"subitem_subject":"dengue","subitem_subject_scheme":"Other"},{"subitem_subject":"human","subitem_subject_scheme":"Other"},{"subitem_subject":"immune response","subitem_subject_scheme":"Other"},{"subitem_subject":"innate immunity","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon production","subitem_subject_scheme":"Other"},{"subitem_subject":"mosquito","subitem_subject_scheme":"Other"},{"subitem_subject":"nonhuman","subitem_subject_scheme":"Other"},{"subitem_subject":"pathogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"review","subitem_subject_scheme":"Other"},{"subitem_subject":"T lymphocyte activation","subitem_subject_scheme":"Other"},{"subitem_subject":"virus transmission","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dengue and Soluble Mediators of the Innate Immune System","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dengue and Soluble Mediators of the Innate Immune System"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-12-05"},"publish_date":"2012-12-05","publish_status":"0","recid":"9341","relation_version_is_last":true,"title":["Dengue and Soluble Mediators of the Innate Immune System"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:48:19.981681+00:00"}