{"created":"2023-05-15T16:29:22.528092+00:00","id":94,"links":{},"metadata":{"_buckets":{"deposit":"2816000e-5dbc-4422-8e3a-586186f66952"},"_deposit":{"created_by":2,"id":"94","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"94"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000094","sets":["10:11"]},"author_link":["480","481","482","485","483","484"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"38","bibliographicPageStart":"e22214","bibliographicVolumeNumber":"99","bibliographic_titles":[{"bibliographic_title":"Medicine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Anti-thyroid peroxidase antibody (TPO-Ab), which is the known cause of autoimmune thyroid disease, enhances proinflammatory cytokine responses. Since low-grade inflammation is a known risk factor for atherosclerosis, a normal range of TPO-Ab (TPO-Ab negative) could be positively \nassociated with atherosclerosis among participants with normal thyroid function. However, no study reported the association between normal range of TPO-Ab and atherosclerosis among eu-thyroid participants. A cross-sectional study was conducted with 1165 Japanese individuals\n with normal thyroid function (ie, normal range of free triiodothyronine [free T3] and free thyroxine [free T4]), aged 40 to 74 years, who participated in an annual health checkup in 2014. Among the study population, 115 were diagnosed as having atherosclerosis.\n A normal range value of TPO-Ab titer is revealed to be positively associated with atherosclerosis; sex, age, thyroid function\n (free T3 and thyroid-stimulating hormone), and known cardiovascular risk factor adjusted odds ratio and 95% confidence interval of atherosclerosis for logarithmic values of TPO-Ab was 2.23 (1.11, 4.47). When we limited the analysis to participants with normal levels of thyroid-stimulating hormone, this association became slightly stronger (2.65 [1.27,5.51]). Among the eu-thyroid general population, a normal range of TPO-Ab titer is revealed to be positively associated with atherosclerosis. Even though a TPO-Ab titer is not clinically relevant and is not associated with autoimmune thyroid disease, it could influence endothelial remodeling including atherosclerosis.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Medicine, 99(38), e22214; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wolters Klwer Health, Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1097/MD.0000000000022214","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c2020 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CC BY-NC), where it is permissible todownload, share, remix, transform,and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00257974","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"15365964","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shin-Ya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Noguchi, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashida, Naomi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-16"}],"displaytype":"detail","filename":"Medicine99_22214.pdf","filesize":[{"value":"204.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Medicine99_22214.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/94/files/Medicine99_22214.pdf"},"version_id":"3c13ef63-f57e-47e1-93df-17b23dda8815"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anti-thyroid peroxidase antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"atherosclerosis","subitem_subject_scheme":"Other"},{"subitem_subject":"normal thyroid function","subitem_subject_scheme":"Other"},{"subitem_subject":"thyroid hormone","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Normal range of anti?thyroid peroxidase antibody (TPO-Ab) and atherosclerosis among eu-thyroid population","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Normal range of anti?thyroid peroxidase antibody (TPO-Ab) and atherosclerosis among eu-thyroid population"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-08"},"publish_date":"2020-10-08","publish_status":"0","recid":"94","relation_version_is_last":true,"title":["Normal range of anti?thyroid peroxidase antibody (TPO-Ab) and atherosclerosis among eu-thyroid population"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:21:37.857722+00:00"}