{"created":"2023-05-15T16:29:59.327641+00:00","id":951,"links":{},"metadata":{"_buckets":{"deposit":"a7e786b6-877c-4878-ab1c-b37d6f16ae33"},"_deposit":{"created_by":2,"id":"951","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"951"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000951","sets":["10:11"]},"author_link":["4492","4495","4498","4493","4496","4497","4494"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-09-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"1157","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Cells"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Poly(ADP-ribose) polymerase (Parp)-1 catalyzes polyADP-ribosylation using NAD+ and is involved in the DNA damage response, genome stability, and transcription. In this study, we demonstrated that aged Parp-1-/- mouse incisors showed more frequent dental dysplasia in both ICR/129Sv mixed background and C57BL/6 strain compared to aged Parp-1+/+ incisors, suggesting that Parp-1 deficiency could be involved in development of dental dysplasia at an advanced age. Computed tomography images confirmed that dental dysplasia was observed at significantly higher incidences in Parp-1-/- mice. The relative calcification levels of Parp-1-/- incisors were higher in both enamel and dentin (p < 0.05). Immunohistochemical analysis revealed (1) Parp-1 positivity in ameloblasts and odontoblasts in Parp-1+/+ incisor, (2) weaker dentin sialoprotein positivity in dentin of Parp-1-/- incisor, and (3) bone sialoprotein positivity in dentin of Parp-1-/- incisor, suggesting ectopic osteogenic formation in dentin of Parp-1-/- incisor. These results indicate that Parp-1 deficiency promotes odontogenic failure in incisors at an advanced age. Parp-1 deficiency did not affect dentinogenesis during the development of mice, suggesting that Parp-1 is not essential in dentinogenesis during development but is possibly involved in the regulation of continuous dentinogenesis in the incisors at an advanced age.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cells, 8(10), art.no.1157; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/cells8101157","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20734409","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujihara, Hisako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nozaki, Tadashige"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsutsumi, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Isumi, Mayu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimoda, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamada, Yoshiki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masutani, Mitsuko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"Cells8_1157.pdf","filesize":[{"value":"5.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Cells8_1157.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/951/files/Cells8_1157.pdf"},"version_id":"c9635bf3-3292-437b-b18c-64dc45529ca5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"poly(ADP-ribose) polymerase-1","subitem_subject_scheme":"Other"},{"subitem_subject":"aged mice","subitem_subject_scheme":"Other"},{"subitem_subject":"knockout mice","subitem_subject_scheme":"Other"},{"subitem_subject":"dental dysplasia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Spontaneous Development of Dental Dysplasia in Aged Parp-1 Knockout Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Spontaneous Development of Dental Dysplasia in Aged Parp-1 Knockout Mice"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-17"},"publish_date":"2020-07-17","publish_status":"0","recid":"951","relation_version_is_last":true,"title":["Spontaneous Development of Dental Dysplasia in Aged Parp-1 Knockout Mice"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:10:24.552060+00:00"}