@article{oai:nagasaki-u.repo.nii.ac.jp:00009558,
 author = {Urata, Shuzo and Ngo, Nhi and de, la Torre  Juan Carlos},
 issue = {8},
 journal = {Journal of Virology},
 month = {Apr},
 note = {Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever (HF) disease in humans and pose a significant public health concern in regions where they are endemic. On the other hand, evidence indicates that the globally distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway participates in many cellular processes, including cell survival and differentiation, and also has been shown to play important roles in different steps of the life cycles of a variety of viruses. Here we report that the inhibition of the PI3K/Akt pathway inhibited budding and to a lesser extent RNA synthesis, but not cell entry, of LCMV. Accordingly, BEZ-235, a PI3K inhibitor currently in cancer clinical trials, inhibited LCMV multiplication in cultured cells. These findings, together with those previously reported for Junin virus (JUNV), indicate that targeting the PI3K/Akt pathway could represent a novel antiviral strategy to combat human-pathogenic arenaviruses., Journal of Virology, 86(8), pp.4578-4585; 2012},
 pages = {4578--4585},
 title = {The PI3K/Akt Pathway Contributes to Arenavirus Budding},
 volume = {86},
 year = {2012}
}