{"created":"2023-05-15T16:36:29.903333+00:00","id":9558,"links":{},"metadata":{"_buckets":{"deposit":"0344b005-bd75-4d06-b74d-75c178169c24"},"_deposit":{"created_by":2,"id":"9558","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"9558"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00009558","sets":["35:36"]},"author_link":["38576","38574","38575"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"4585","bibliographicPageStart":"4578","bibliographicVolumeNumber":"86","bibliographic_titles":[{"bibliographic_title":"Journal of Virology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever (HF) disease in humans and pose a significant public health concern in regions where they are endemic. On the other hand, evidence indicates that the globally distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway participates in many cellular processes, including cell survival and differentiation, and also has been shown to play important roles in different steps of the life cycles of a variety of viruses. Here we report that the inhibition of the PI3K/Akt pathway inhibited budding and to a lesser extent RNA synthesis, but not cell entry, of LCMV. Accordingly, BEZ-235, a PI3K inhibitor currently in cancer clinical trials, inhibited LCMV multiplication in cultured cells. These findings, together with those previously reported for Junin virus (JUNV), indicate that targeting the PI3K/Akt pathway could represent a novel antiviral strategy to combat human-pathogenic arenaviruses.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Virology, 86(8), pp.4578-4585; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Microbiology"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1128/JVI.06604-11","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012, American Society for Microbiology."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022538X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Urata, Shuzo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ngo, Nhi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"de, la Torre  Juan Carlos"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"JV86_4578.pdf","filesize":[{"value":"868.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JV86_4578.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/9558/files/JV86_4578.pdf"},"version_id":"6794accc-9668-467f-8db2-2b93dfda0a70"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"1 (1 cyano 1 methylethyl) 3 methyl 8 (3 quinolinyl)imidazo[4,5 c]quinolin 2(1h,3h) one","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphatidylinositol 3 kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"protein kinase B","subitem_subject_scheme":"Other"},{"subitem_subject":"rapamycin","subitem_subject_scheme":"Other"},{"subitem_subject":"virus RNA","subitem_subject_scheme":"Other"},{"subitem_subject":"antiviral activity","subitem_subject_scheme":"Other"},{"subitem_subject":"article","subitem_subject_scheme":"Other"},{"subitem_subject":"cell culture","subitem_subject_scheme":"Other"},{"subitem_subject":"controlled study","subitem_subject_scheme":"Other"},{"subitem_subject":"drug effect","subitem_subject_scheme":"Other"},{"subitem_subject":"drug mechanism","subitem_subject_scheme":"Other"},{"subitem_subject":"drug targeting","subitem_subject_scheme":"Other"},{"subitem_subject":"enzyme activity","subitem_subject_scheme":"Other"},{"subitem_subject":"enzyme inhibition","subitem_subject_scheme":"Other"},{"subitem_subject":"genetic transcription","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphocytic choriomeningitis virus","subitem_subject_scheme":"Other"},{"subitem_subject":"priority journal","subitem_subject_scheme":"Other"},{"subitem_subject":"protein targeting","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA replication","subitem_subject_scheme":"Other"},{"subitem_subject":"virogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"virus entry","subitem_subject_scheme":"Other"},{"subitem_subject":"virus gene","subitem_subject_scheme":"Other"},{"subitem_subject":"virus inhibition","subitem_subject_scheme":"Other"},{"subitem_subject":"virus release","subitem_subject_scheme":"Other"},{"subitem_subject":"Animals","subitem_subject_scheme":"Other"},{"subitem_subject":"Arenavirus","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Line","subitem_subject_scheme":"Other"},{"subitem_subject":"Cercopithecus aethiops","subitem_subject_scheme":"Other"},{"subitem_subject":"Chromones","subitem_subject_scheme":"Other"},{"subitem_subject":"Gene Expression Regulation, Viral","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_scheme":"Other"},{"subitem_subject":"Imidazoles","subitem_subject_scheme":"Other"},{"subitem_subject":"Lassa virus","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphocytic choriomeningitis virus","subitem_subject_scheme":"Other"},{"subitem_subject":"Morpholines","subitem_subject_scheme":"Other"},{"subitem_subject":"Phosphatidylinositol 3-Kinases","subitem_subject_scheme":"Other"},{"subitem_subject":"Proto-Oncogene Proteins c-akt","subitem_subject_scheme":"Other"},{"subitem_subject":"Quinolines","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA, Viral","subitem_subject_scheme":"Other"},{"subitem_subject":"Signal Transduction","subitem_subject_scheme":"Other"},{"subitem_subject":"Sirolimus","subitem_subject_scheme":"Other"},{"subitem_subject":"Virus Internalization","subitem_subject_scheme":"Other"},{"subitem_subject":"Virus Release","subitem_subject_scheme":"Other"},{"subitem_subject":"Virus Replication","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The PI3K/Akt Pathway Contributes to Arenavirus Budding","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The PI3K/Akt Pathway Contributes to Arenavirus Budding"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-01-09"},"publish_date":"2013-01-09","publish_status":"0","recid":"9558","relation_version_is_last":true,"title":["The PI3K/Akt Pathway Contributes to Arenavirus Budding"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:42:56.964504+00:00"}