{"created":"2023-05-15T16:36:29.945211+00:00","id":9559,"links":{},"metadata":{"_buckets":{"deposit":"746e5863-a4b3-4d88-ba43-c141948d97e5"},"_deposit":{"created_by":2,"id":"9559","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"9559"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00009559","sets":["29:30"]},"author_link":["38581","38583","38579","38584","38577","38582","38580","38578"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"4955","bibliographicPageStart":"4947","bibliographicVolumeNumber":"86","bibliographic_titles":[{"bibliographic_title":"Journal of Virology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abnormal prion protein (PrP Sc) generated from the cellular isoform of PrP (PrP C) is assumed to be the main or sole component of the pathogen, called prion, of transmissible spongiform encephalopathies (TSE). Because PrP is a host-encoded protein, acquired immune responses are not induced in TSE. Meanwhile, activation of the innate immune system has been suggested to partially block the progression of TSE; however, the mechanism is not well understood. To further elucidate the role of the innate immune system in prion infection, we investigated the function of interferon regulatory factor 3 (IRF3), a key transcription factor of the MyD88-independent type I interferon (IFN) production pathway. We found that IRF3-deficient mice exhibited significantly earlier onset with three murine TSE strains, namely, 22L, FK-1, and murine bovine spongiform encephalopathy (mBSE), following intraperitoneal transmission, than with wild-type controls. Moreover, overexpression of IRF3 attenuated prion infection in the cell culture system, while PrP Sc was increased in prion-infected cells treated with small interfering RNAs (siRNAs) against IRF3, suggesting that IRF3 negatively regulates PrP Sc formation. Our findings provide new insight into the role of the host innate immune system in the pathogenesis of prion diseases.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Virology, 86(9), pp.4947-4955; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Microbiology"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1128/JVI.06326-11","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012, American Society for Microbiology."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022538X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishibashi, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Atarashi, Ryuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fuse, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagaki, Takehiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Naohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Katsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honda, Kenya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishida, Noriyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"JV86_4947.pdf","filesize":[{"value":"811.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JV86_4947.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/9559/files/JV86_4947.pdf"},"version_id":"1791e3a4-fa81-4cf1-8108-ffee953b0728"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"interferon regulatory factor 3","subitem_subject_scheme":"Other"},{"subitem_subject":"prion protein","subitem_subject_scheme":"Other"},{"subitem_subject":"small interfering RNA","subitem_subject_scheme":"Other"},{"subitem_subject":"animal cell","subitem_subject_scheme":"Other"},{"subitem_subject":"animal experiment","subitem_subject_scheme":"Other"},{"subitem_subject":"animal model","subitem_subject_scheme":"Other"},{"subitem_subject":"animal tissue","subitem_subject_scheme":"Other"},{"subitem_subject":"article","subitem_subject_scheme":"Other"},{"subitem_subject":"bovine spongiform encephalopathy","subitem_subject_scheme":"Other"},{"subitem_subject":"cell culture","subitem_subject_scheme":"Other"},{"subitem_subject":"controlled study","subitem_subject_scheme":"Other"},{"subitem_subject":"immunopathogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"innate immunity","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse","subitem_subject_scheme":"Other"},{"subitem_subject":"neuroprotection","subitem_subject_scheme":"Other"},{"subitem_subject":"nonhuman","subitem_subject_scheme":"Other"},{"subitem_subject":"nucleotide sequence","subitem_subject_scheme":"Other"},{"subitem_subject":"prion disease","subitem_subject_scheme":"Other"},{"subitem_subject":"priority journal","subitem_subject_scheme":"Other"},{"subitem_subject":"signal transduction","subitem_subject_scheme":"Other"},{"subitem_subject":"virus transmission","subitem_subject_scheme":"Other"},{"subitem_subject":"wild type","subitem_subject_scheme":"Other"},{"subitem_subject":"Brain","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Line","subitem_subject_scheme":"Other"},{"subitem_subject":"Interferon Regulatory Factor-3","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice, Inbred C57BL","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice, Knockout","subitem_subject_scheme":"Other"},{"subitem_subject":"Prion Diseases","subitem_subject_scheme":"Other"},{"subitem_subject":"PrPSc Proteins","subitem_subject_scheme":"Other"},{"subitem_subject":"Signal Transduction","subitem_subject_scheme":"Other"},{"subitem_subject":"Spleen","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-01-09"},"publish_date":"2013-01-09","publish_status":"0","recid":"9559","relation_version_is_last":true,"title":["Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:42:55.016881+00:00"}