{"created":"2023-05-15T16:29:59.895158+00:00","id":964,"links":{},"metadata":{"_buckets":{"deposit":"008f3aae-bc3a-4d70-90e8-6258d6edec2a"},"_deposit":{"created_by":2,"id":"964","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"964"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000964","sets":["10:11"]},"author_link":["4602","4614","4601","4613","4598","4606","4611","4604","4610","4615","4612","4608","4600","4603","4609","4597","4607","4599","4605"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"175","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Arthritis Research & Therapy"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND: Most patients with systemic lupus erythematosus (SLE) progress to lupus nephritis (LN) within 5?years of their SLE diagnosis, although it is not uncommon for LN to develop at later time points. Here we evaluated the clinical features of early- and late-onset LN. PATIENTS AND METHODS: We retrospectively analyzed the cases of 184 of the 201 patients who underwent a renal biopsy at Nagasaki University Hospital and associated community hospitals between 1990 and 2016 and were diagnosed as having LN. Early onset was defined as the development of LN within the first 5?years after the patient's SLE diagnosis, and late onset was defined as LN development >?5?years post-diagnosis. We analyzed the complete renal response (CR) at 6 and 12?months after induction therapy, the classification of renal pathology, and the mortality of the early- and late-onset LN groups. RESULTS: The mean follow-up duration after the renal biopsy was 123?±?85?months. There were 113 (61.4%) early-onset patients and 71 (38.6%) late-onset patients. A multivariate analysis revealed that the following factors were predictive of CR: at 6?months: female sex (odds ratio [OR] 3.93, 95% confidence interval [CI] 1.31-11.77, p?=?0.010), proteinuria (OR 0.83, 95% CI 0.71-0.97, p?=?0.009), index of activity (0-24) (OR 0.83, 95% CI 0.70-0.99, p?=?0.030), and early-onset LN (OR 2.39, 95% CI 1.15-4.98, p?=?0.018); at 12?months: female sex (OR 3.60, 95% CI 1.32-9.83, p?=?0.013), mixed LN (OR 0.18, 95% CI 0.04-0.80, p?=?0.024), index of activity (0-24) (OR 0.80, 95% CI 0.68-0.94, p?=?0.007), and early-onset LN (OR 2.10, 95% CI 1.05-4.23, p?=?0.035). In a Cox proportional hazards and Fine-Gray regression model, the early-onset LN group had a significantly better mortality rate than the late-onset LN group (p?=?0.038 and p?=?0.043, respectively). CONCLUSIONS: In our cohort, early-onset LN was a better predictor of CR at 6 and 12?months than late-onset LN. Our results suggest that early-onset LN patients had lower mortality than late-onset LN patients.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Arthritis research & therapy, 22(1), art.no.175; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s13075-020-02271-3","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"cThe Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons　licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain　permission directly from the copyright holder. To view a copy of this licence,visit http://creativecommons.org/licenses/by/4.0/.The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14786362","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ichinose, Kunihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitamura, Mineaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shuntaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujikawa, Keita"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horai, Yoshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuoka, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuboi, Masahiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nonaka, Fumiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Toshimasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sumiyoshi, Remi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koga, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shin-ya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwamoto, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Igawa, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamai, Mami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Origuchi, Tomoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishino, Tomoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Atsushi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"ART22_175.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ART22_175.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/964/files/ART22_175.pdf"},"version_id":"ed268bdb-b123-4453-9281-b58a102ad566"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Complete renal response","subitem_subject_scheme":"Other"},{"subitem_subject":"Early onset","subitem_subject_scheme":"Other"},{"subitem_subject":"Late onset","subitem_subject_scheme":"Other"},{"subitem_subject":"Lupus nephritis","subitem_subject_scheme":"Other"},{"subitem_subject":"Systemic lupus erythematosus","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparison of complete renal response and mortality in early- and late-onset lupus nephritis: a multicenter retrospective study of a Japanese cohort","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of complete renal response and mortality in early- and late-onset lupus nephritis: a multicenter retrospective study of a Japanese cohort"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-07"},"publish_date":"2020-08-07","publish_status":"0","recid":"964","relation_version_is_last":true,"title":["Comparison of complete renal response and mortality in early- and late-onset lupus nephritis: a multicenter retrospective study of a Japanese cohort"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:10:11.441434+00:00"}