@article{oai:nagasaki-u.repo.nii.ac.jp:00000966,
 author = {Yamayoshi, Asako and Oyama, Shota and Kishimoto, Yusuke and Konishi, Ryo and Yamamoto, Tsuyoshi and Kobori, Akio and Harada, Hiroshi and Ashihara, Eishi and Sugiyama, Hiroshi and Murakami, Akira},
 issue = {6},
 journal = {Pharmaceutics},
 month = {Jun},
 note = {MicroRNAs in exosomes (exosomal miRNAs) are considered as significant targets for cancer therapy. Anti-miR oligonucleotides are often used for the functional inhibition of miRNAs; however, there are no studies regarding the regulation of exosomal miRNA functions. In this study, we attempted to develop a novel drug delivery system using anti-exosome antibody?anti-miR oligonucleotide complexes (ExomiR-Tracker) to hijack exosomes to carry anti-miR oligonucleotides inside exosome-recipient cells. We found that ExomiR-Tracker bound to the exosomes, and then the complexes were introduced into the recipient cells. We also found that anti-miR oligonucleotides introduced into the recipient cells can exhibit inhibitory effects on exosomal miRNA functions in vitro and in vivo. We believe that our strategy would be a promising one for targeting exosomal miRNAs., Pharmaceutics, 12(6), art.no.545; 2020},
 title = {Development of Antibody?Oligonucleotide Complexes for Targeting Exosomal MicroRNA},
 volume = {12},
 year = {2020}
}