{"created":"2023-05-15T16:29:59.984743+00:00","id":966,"links":{},"metadata":{"_buckets":{"deposit":"84088e5f-bc8c-4a57-b650-670f7b43f838"},"_deposit":{"created_by":2,"id":"966","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"966"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000966","sets":["10:11"]},"author_link":["4634","4627","4629","4628","4625","4626","4630","4633","4632","4631"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"545","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Pharmaceutics"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"MicroRNAs in exosomes (exosomal miRNAs) are considered as significant targets for cancer therapy. Anti-miR oligonucleotides are often used for the functional inhibition of miRNAs; however, there are no studies regarding the regulation of exosomal miRNA functions. In this study, we attempted to develop a novel drug delivery system using anti-exosome antibody?anti-miR oligonucleotide complexes (ExomiR-Tracker) to hijack exosomes to carry anti-miR oligonucleotides inside exosome-recipient cells. We found that ExomiR-Tracker bound to the exosomes, and then the complexes were introduced into the recipient cells. We also found that anti-miR oligonucleotides introduced into the recipient cells can exhibit inhibitory effects on exosomal miRNA functions in vitro and in vivo. We believe that our strategy would be a promising one for targeting exosomal miRNAs.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Pharmaceutics, 12(6), art.no.545; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/pharmaceutics12060545","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"19994923","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamayoshi, Asako"}],"nameIdentifiers":[{"nameIdentifier":"4625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oyama, Shota"}],"nameIdentifiers":[{"nameIdentifier":"4626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kishimoto, Yusuke"}],"nameIdentifiers":[{"nameIdentifier":"4627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konishi, Ryo"}],"nameIdentifiers":[{"nameIdentifier":"4628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Tsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"4629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobori, Akio"}],"nameIdentifiers":[{"nameIdentifier":"4630","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Harada, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"4631","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ashihara, Eishi"}],"nameIdentifiers":[{"nameIdentifier":"4632","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugiyama, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"4633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Akira"}],"nameIdentifiers":[{"nameIdentifier":"4634","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"Pharmaceutics12_545.pdf","filesize":[{"value":"7.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Pharmaceutics12_545.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/966/files/Pharmaceutics12_545.pdf"},"version_id":"cb4fdf28-4ce3-43a4-9ad4-d48e28a4903a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug delivery system","subitem_subject_scheme":"Other"},{"subitem_subject":"Exosome","subitem_subject_scheme":"Other"},{"subitem_subject":"MicroRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"Nucleic acid drug","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Development of Antibody?Oligonucleotide Complexes for Targeting Exosomal MicroRNA","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of Antibody?Oligonucleotide Complexes for Targeting Exosomal MicroRNA"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-07"},"publish_date":"2020-08-07","publish_status":"0","recid":"966","relation_version_is_last":true,"title":["Development of Antibody?Oligonucleotide Complexes for Targeting Exosomal MicroRNA"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:10:07.269013+00:00"}