@article{oai:nagasaki-u.repo.nii.ac.jp:00000968,
 author = {Sakamoto, Yuki and Yanamoto, Souichi and Adachi, Masaki and Tsuda, Shoma and Furukawa, Kohei and Naruse, Tomofumi and Umeda, Masahiro},
 issue = {4},
 journal = {Molecular and Clinical Oncology},
 month = {Feb},
 note = {Undifferentiated carcinoma of the oral cavity is a rare and possibly fatal malignant neoplasm. We present here a case of
 undifferentiated carcinoma of the oral tongue, which responded well to chemotherapy with cisplatin, 5-fluorouracil, 
and cetuximab. A 59-year-old man was referred to our hospital for a large tumor of the tongue. Physical examination revealed 
an ulcerative tumor, approximately 50 mm in diameter, on the right edge of the tongue and swelling of multiple cervical
 lymph nodes; therefore, the clinical diagnosis was tongue cancer (T4aN2bM0). The histological diagnosis from a biopsy 
specimen was undifferentiated carcinoma; we tested the sample for human papilloma virus immunoreactivity, which was positive. 
The patient then underwent chemotherapy with cisplatin, 5-fluorouracil and cetuximab. The tumor’s size decreased markedly 
after two courses of chemotherapy, but the treatment was stopped due to the patient'various mental problems and pneumonia; 
he died 6 months after the initial visit. Our encounter with this patient suggests that cetuximab treatment is a good option
 for HPV-positive undifferentiated carcinoma of the oral tongue., Molecular and Clinical Oncology, 10(4), pp.446-450; 2019},
 pages = {446--450},
 title = {Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report},
 volume = {10},
 year = {2019}
}