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The present study was carried out to determine whether inhalation of hydrogen (H 2) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine. Design. In anesthetized open-chest swine, myocardial stunning was produced by 12-minute occlusion of left anterior descending coronary artery (LAD) followed by 90-minute reperfusion in the first study. Group A inhaled 100% oxygen, and group B inhaled 2% H 2 plus 98% oxygen during ischemia and reperfusion. In the second study, myocardial infarction was produced by 40-minute occlusion of LAD followed by 120-minute reperfusion. Group C inhaled 100% oxygen during ischemia and reperfusion. Group D inhaled 2% H 2 plus 98% oxygen. Group E inhaled 4% H 2 plus 96% oxygen. Results. The change of segment shortening (%SS) from baseline at 90 minutes after reperfusion in group B was 74±13 (mean ± SD) %, which was significantly higher than that in group A (48±15%). 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Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine
http://hdl.handle.net/10069/29175
http://hdl.handle.net/10069/291755e091ba6-fc38-4ddd-8b4e-4bb217705dbb
名前 / ファイル | ライセンス | アクション |
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SCJ46_183.pdf (253.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-07-01 | |||||
タイトル | ||||||
タイトル | Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hydrogen gas | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myocardial infarction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myocardial stunning | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sakai, Kazuyuki
× Sakai, Kazuyuki× Cho, Sungsam× Shibata, Itsuko× Yoshitomi, Osamu× Maekawa, Takuji× Sumikawa, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives. The present study was carried out to determine whether inhalation of hydrogen (H 2) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine. Design. In anesthetized open-chest swine, myocardial stunning was produced by 12-minute occlusion of left anterior descending coronary artery (LAD) followed by 90-minute reperfusion in the first study. Group A inhaled 100% oxygen, and group B inhaled 2% H 2 plus 98% oxygen during ischemia and reperfusion. In the second study, myocardial infarction was produced by 40-minute occlusion of LAD followed by 120-minute reperfusion. Group C inhaled 100% oxygen during ischemia and reperfusion. Group D inhaled 2% H 2 plus 98% oxygen. Group E inhaled 4% H 2 plus 96% oxygen. Results. The change of segment shortening (%SS) from baseline at 90 minutes after reperfusion in group B was 74±13 (mean ± SD) %, which was significantly higher than that in group A (48±15%). Myocardial infarct size in group E (32±10%), but not in group D (40±9%) was smaller than that in group C (46±6%). Conclusions. Inhalation of 2% H 2 gas improves myocardial stunning, and inhalation of 4% but not 2% H 2 gas reduces myocardial infarct size in swine. | |||||
書誌情報 |
Scandinavian Cardiovascular Journal 巻 46, 号 3, p. 183-188, 発行日 2012-06 |
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出版者 | ||||||
出版者 | Informa Healthcare | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14017431 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16512006 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/14017431.2012.659676 | |||||
権利 | ||||||
権利情報 | © 2012 Informa Healthcare. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Scandinavian Cardiovascular Journal, 46(3), pp.183-188; 2012 |