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However, the relationship between venous ketone bodies and hepatocellular carcinoma (HCC) is unclear. We investigated whether prognosis of patients with HCC after transcatheter arterial chemoembolization (TACE) was associated with venous blood ketone bodies. Methods: Sixty-eight patients with HCC who underwent TACE were recruited for this study. The venous blood ketone body levels were measured 1 d before (pretreatment) and 7 d after TACE (posttreatment). Skeletal muscle quality was evaluated using the intramuscular adipose tissue content (IMAC). Results: Of the 68 patients, 43 (63.2%) were male, with median age of 73.0 y, and the IMAC was ?0.274 (range ?0.82 to 0.24). The median ketone body levels pre- and posttreatment were 63.0 μmol/L (13?310) and 48.0 μmol/L (8?896), respectively. The cumulative survival rate of patients with total ketone body ratio ([TKBR]: posttreatment/pretreatment total ketone bodies) \u003c1 was 86.6%. The rate with TKBR ?1 was 59.0% at 300 d (P \u003c 0.05). Cox regression analysis identified the TKBR (?1, hazard ratio: 2.954, 95% confidence interval [CI]: 1.040?8.390, P = 0.030) that independently and significantly predicted the patients\u0027 prognoses. Logistic regression analysis revealed the IMAC (\u003e?0.2745, odds ratio: 3.958, 95% CI: 1.137?13.779, P = 0.031) that predicted TKBR. TKBR and IMAC were positively correlated (rS = 0.358, P = 0.003). Conclusions: The changes in the venous ketone body were associated with the muscle status and predicted the prognosis of patients with HCC who underwent TACE. 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Ketone bodies as a predictor of prognosis of hepatocellular carcinoma after transcatheter arterial chemoembolization
http://hdl.handle.net/10069/38418
http://hdl.handle.net/10069/38418f72e4a6b-7337-4116-a7e6-231e610ed5cf
名前 / ファイル | ライセンス | アクション |
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Nutrition50_97.pdf (401.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-07-01 | |||||
タイトル | ||||||
タイトル | Ketone bodies as a predictor of prognosis of hepatocellular carcinoma after transcatheter arterial chemoembolization | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cirrhosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Intramuscular adipose tissue content | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liver disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Skeletal muscle quality | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sasaki, Ryu
× Sasaki, Ryu× Taura, Naota× Miyazoe, Yuri× Yamamichi, Shinobu× Nakashiki, Suguru× Yamashima, Mio× Suehiro, Tomoyuki× Honda, Takuya× Shibata, Hidetaka× Ozawa, Eisuke× Miuma, Satoshi× Akazawa, Yuko× Miyaaki, Hisamitsu× Matsumoto, Takehiro× Nakao, Kazuhiko× Ashizawa, Kazuto |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: Arterial ketone bodies, which reflect liver function, have been investigated. However, the relationship between venous ketone bodies and hepatocellular carcinoma (HCC) is unclear. We investigated whether prognosis of patients with HCC after transcatheter arterial chemoembolization (TACE) was associated with venous blood ketone bodies. Methods: Sixty-eight patients with HCC who underwent TACE were recruited for this study. The venous blood ketone body levels were measured 1 d before (pretreatment) and 7 d after TACE (posttreatment). Skeletal muscle quality was evaluated using the intramuscular adipose tissue content (IMAC). Results: Of the 68 patients, 43 (63.2%) were male, with median age of 73.0 y, and the IMAC was ?0.274 (range ?0.82 to 0.24). The median ketone body levels pre- and posttreatment were 63.0 μmol/L (13?310) and 48.0 μmol/L (8?896), respectively. The cumulative survival rate of patients with total ketone body ratio ([TKBR]: posttreatment/pretreatment total ketone bodies) <1 was 86.6%. The rate with TKBR ?1 was 59.0% at 300 d (P < 0.05). Cox regression analysis identified the TKBR (?1, hazard ratio: 2.954, 95% confidence interval [CI]: 1.040?8.390, P = 0.030) that independently and significantly predicted the patients' prognoses. Logistic regression analysis revealed the IMAC (>?0.2745, odds ratio: 3.958, 95% CI: 1.137?13.779, P = 0.031) that predicted TKBR. TKBR and IMAC were positively correlated (rS = 0.358, P = 0.003). Conclusions: The changes in the venous ketone body were associated with the muscle status and predicted the prognosis of patients with HCC who underwent TACE. The venous ketone bodies could be a new predictor of the prognosis of HCC patients after TACE. | |||||
書誌情報 |
Nutrition 巻 50, p. 97-103, 発行日 2018-06 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 08999007 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.nut.2017.12.015 | |||||
権利 | ||||||
権利情報 | c 2018 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nutrition, 50, pp.97-103; 2018 |