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Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells.
http://hdl.handle.net/10069/27414
http://hdl.handle.net/10069/27414008a4a2b-610d-4b8a-8c5a-8670d67a2a75
名前 / ファイル | ライセンス | アクション |
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LeuLym52_1108.pdf (904.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-07-01 | |||||
タイトル | ||||||
タイトル | Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adhesion molecules | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adult T-cell leukemia/lymphoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MUC1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hasegawa, Hiroo
× Hasegawa, Hiroo× Komoda, Minori× Yamada, Yasuaki× Yonezawa, Suguru× Tsutsumida, Hideaki× Nagai, Kazuhiro× Atogami, Sunao× Tsuruda, Kazuto× Osaka, Akemi× Sasaki, Daisuke× Yanagihara, Katsunori× Imaizumi, Yoshitaka× Tsukasaki, Kunihiro× Miyazaki, Yasushi× Kamihira, Shimeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aberrant overexpression of membrane-associated mucin (MUC1) is implicated in the pathogenesis of cancer, particularly of adenocarcinomas. Adult T-cell leukemia/lymphoma (ATL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), exhibits invasive tropism into various organs, resulting in disease progression and resistance to treatment. In the present study, we showed that MUC1 is overexpressed exclusively in cells of ATL among hematological malignancies. Furthermore, increased expression of MUC1 correlated with a poor prognosis, suggesting MUC1 to be a prognostic marker in ATL. Various functional analyses with knockdown experiments using a specific siRNA for MUC1 revealed that MUC1 is involved in cell growth, cell aggregation, and resistance to apoptosis. Although it has been shown that the anti-adhesive properties of MUC1 facilitate migration and metastasis of tumor cells, our findings indicated that MUC1 contributes to cell-cell adhesion. Mucins thus seem to play a role in the pathogenesis and/or progression of ATL. | |||||
書誌情報 |
Leukemia & Lymphoma 巻 52, 号 6, p. 1108-1117, 発行日 2011-06 |
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出版者 | ||||||
出版者 | Informa UK | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10428194 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10292403 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1077558X | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21599593 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/10428194.2011.559671 | |||||
権利 | ||||||
権利情報 | © 2011 Informa UK, Ltd. | |||||
権利 | ||||||
権利情報 | This is an electronic version of an article published in Leukemia & Lymphoma, 52(6), pp.1108-1117; 2011. Leukemia & Lymphoma is available online at: http://dx.doi.org/10.3109/10428194.2011.559671 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Leukemia & Lymphoma, 52(6), pp.1108-1117; 2011 |