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Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement: Comparison with EGFR mutation and ALK/EGFR-negative lung cancer
http://hdl.handle.net/10069/38902
http://hdl.handle.net/10069/38902376e4243-011e-451e-b8f2-6956cfb26b30
名前 / ファイル | ライセンス | アクション |
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ThoCan2019MoriMio.pdf (712.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-03-26 | |||||
タイトル | ||||||
タイトル | Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement: Comparison with EGFR mutation and ALK/EGFR-negative lung cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anaplastic lymphoma kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | computed tomography | |||||
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主題Scheme | Other | |||||
主題 | epidermal growth factor receptor | |||||
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主題Scheme | Other | |||||
主題 | histological subtyp | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | enon-small cell lung cancer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mori, Mio
× Mori, Mio× Hayashi, Hideyuki× Fukuda, Minoru× Honda, Sumihisa× Kitazaki, Takeshi× Shigematsu, Kazuto× Matsuyama, Naohiro× Otsubo, Mayumi× Nagayasu, Takeshi× Hashisako, Mikiko× Tabata, Kazuhiro× Uetani, Masataka× Ashizawa, Kazuto |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The study was conducted to evaluate the clinical and computed tomography (CT) findings of non-small cell lung cancer (NSCLC) patients to distinguish between ALK gene rearrangement, EGFR mutation,and non-ALK/EGFR (no genetic abnormalities). Methods: We enrolled 201 patients with primary NSCLC who had undergone molecular testing for both ALK gene rearrangement and EGFR mutation. The clinical features and CT findings of the main lesion and associated pulmonary abnormalities were investigated.Results: Female gender (P = 0.0043 vs. non-ALK/EGFR), young age (P = 0.0156 vs. EGFR),and a light or never smoking history (P = 0.0039 vs. non-ALK/EGFR) were significant clinical characteristics of NSCLC with ALK gene rearrangement. The significant CT characteristics compared to NSCLC with EGFR mutation were a large mass (P = 0.0155), solid mass (P = 0.0048), and no air bronchogram (P = 0.0148). A central location (P = 0.0322) and lymphadenopathy (P =0.0353) were also more frequently observed. Coexisting emphysema was significantly less frequent in NSCLC patients with ALK gene rearrangement (P = 0.0135) than non-ALK/EGFR. Conclusions: NSCLC with ALK gene rearrangement was more likely to develop in younger women with a light or never smoking history. The characteristic CT findings of NSCLC with ALK gene rearrangement were a large solid mass, less air bronchogram, a central location, and lymphadenopathy. | |||||
書誌情報 |
Thoracic Cancer@@@Thoracic Cancer 巻 10, 号 4, p. 872-879, 発行日 2019-02-27 |
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出版者 | ||||||
出版者 | John Wiley & Sons Australia, Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17597706 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/1759-7714.13017 | |||||
権利 | ||||||
権利情報 | c 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thoracic Cancer, 10(4), pp.872-879; 2019 |