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A Novel Role for Thyroid Hormone Receptor Beta in Cellular Radiosensitivity
http://hdl.handle.net/10069/20896
http://hdl.handle.net/10069/2089699057104-1384-4894-98df-24b6911779b7
名前 / ファイル | ライセンス | アクション |
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110006570524.pdf (2.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-02-02 | |||||
タイトル | ||||||
タイトル | A Novel Role for Thyroid Hormone Receptor Beta in Cellular Radiosensitivity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Thyroid hormone receptor beta | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiosensitivity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Clonogenic survival | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cellular senescence | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsuse, Michiko
× Matsuse, Michiko× Saenko, Vladimir× Sedliarou, Ilya× Rogounovitch, Tatiana× Nakazawa, Yuka× Mitsytake, Norisato× Akulevich, Natallia× Namba, Hiroyuki× Yamashita, Shunichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Thyroid hormone receptors (THRs) widely govern cell growth, differentiation and metabolism acting in a ligand- and cofactor-dependent manner to modulate tissue-specific gene expression. Given a large variety of genes regulated by THRs and multiplicity of cellular processes potentially influenced by THRs, we addressed the role of THRB (thyroid hormone receptor beta) in cellular radiosensitivity. Wild-type and mutant THRB were overexpressed in several cell lines using an adenovirus-mediated gene delivery and their effects were examined after cell exposure to γ-rays. Wild-type THRB decreased clonogenic survival of the cell lines with low levels of endogenous THRB, retarded their growth and synergized with radiation in decreasing proliferative potential and promoting cellular senescence. These changes were accompanied by the accumulation of p21 (CDKN1A, CIP1, WAF1) and p16 (CDKN2A, INK4a) inhibitors of cyclindependent kinases and by the decrease of Rb (retinoblastoma protein) phosphorylation. Mutant THRB produced a radioprotective effect, attenuated radiation-induced growth inhibition and cellular senescence. The results suggest that THRB may modulate cellular radiosensitivity and stress-induced senescence. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第148号 博士(医学)学位授与年月日:平成20年3月19日 | |||||
書誌情報 |
Journal of Radiation Research 巻 49, 号 1, p. 17-27, 発行日 2008-01 |
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出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
出版者別言語 | ||||||
値 | THE JAPAN RADIATION RESEARCH SOCIETY | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1269/jrr.07065 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2008 by THE JAPAN RADIATION RESEARCH SOCIETY | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Radiation Research, 49(1), pp.17-27; 2008 |