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Use of vonoprazan for management of systemic sclerosis‑related gastroesophageal reflux disease
http://hdl.handle.net/10069/00040472
http://hdl.handle.net/10069/00040472103789d8-28c0-47e6-81df-b4dbaf11cdef
名前 / ファイル | ライセンス | アクション |
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BioRes14_1.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-01-22 | |||||
タイトル | ||||||
タイトル | Use of vonoprazan for management of systemic sclerosis‑related gastroesophageal reflux disease | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Frequency scale for symptoms of gastroesophageal reflux disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gastroesophageal reflux disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proton pump inhibitor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Systemic sclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vonoprazan , | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tabuchi, Maiko
× Tabuchi, Maiko× Minami, Hitomi× Akazawa, Yuko× Ashida, Miwa× Hara, Toshihide× Ichinose, Kunihiro× Kitayama, Moto× Hashiguchi, Keiichi× Matsushima, Kayoko× Yamaguchi, Naoyuki× Takeshima, Fuminao× Kondo, Hisayoshi× Kawakami, Atsushi× Nakao, Kazuhiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Gastroesophageal reflux disease (GERD) in systemic sclerosis (SSc) can significantly reduce a patient's quality of life. GERD in SSc is occasionally resistant to conventional anti-acid treatment. Vonoprazan is an H+/K+-ATPase blocker that is approved in Japan for treatment of GERD. The aim of the present study was to evaluate the efficacy of vonoprazan in SSc-related GERD. The frequency scale for symptoms of GERD (FSSG) scores were collected before and after vono-prazan treatment in 15 SSc patients with GERD. Additionally, endoscopic esophagogastroduodenoscopy was performed in select patients. Conventional proton pump inhibitors or hista-mine-2 receptor antagonists had been previously administered in 93% (14/15) of the patients. Although the baseline esophago-gastroduodenoscopy examination did not show severe erosion in the majority of patients,the mean total FSSG score before vonoprazan treatment was notably high (25.2±10.7) compared to a normal score of <8. After vonoprazan treatment, the FSSG score decreased to 9.6±7.0. The mean improvement rate of the total FSSG, acid reflux and dysmotility scores were 60.8±21.2% (P=0.0004), 67.3±24.8% (P<0.0001) and 55.4±26.0% (P=0.0022), respectively.These results suggest that vonoprazan may be a potentially effective treatment for GERD in patients with SSc. |
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書誌情報 |
Biomedical Reports 巻 14, 号 2, p. 1-8, 発行日 2020-12-17 |
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出版者 | ||||||
出版者 | Spandidos Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2049-9434 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/br.2020.1401 | |||||
権利 | ||||||
権利情報 | © Tabuchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biomedical Reports, 14(2), pp.1-8; 2020 |