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Stem Cell Transplantation Enhances Endogenous Brain Repair after Experimental Stroke
http://hdl.handle.net/10069/35657
http://hdl.handle.net/10069/35657026b5cce-04df-444e-a305-6fea39ca90b1
名前 / ファイル | ライセンス | アクション |
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NMC55_107.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-07-16 | |||||
タイトル | ||||||
タイトル | Stem Cell Transplantation Enhances Endogenous Brain Repair after Experimental Stroke | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Endogenous repair | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stem cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stroke | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transplantation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Horie, Nobutaka
× Horie, Nobutaka× Hiu, Takeshi× Nagata, Izumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Stem cell transplantation for stroke treatment has been a promising therapy in small and large animal models, and many clinical trials are ongoing to establish this strategy in a clinical setting. However, the mechanism underlying functional recovery after stem cell transplantation has not been fully established and there is still a need to determine the ideal subset of stem cells for such therapy. We herein reviewed the recent evidences showing the underlying mechanism of functional recovery after cell transplantation, focusing on endogenous brain repair. First, angiogenesis/neovascularization is promoted by trophic factors including vascular endothelial growth factor secreted from stem cells, and stem cells migrated to the lesion along with the vessels. Second, axonal sprouting, dendritic branching, and synaptogenesis were enhanced altogether in the both ipsilateral and contralateral hemisphere remapping the pyramidal tract across the board. Finally, endogenous neurogenesis was also enhanced although little is known how much these neurogenesis contribute to the functional recovery. Taken together, it is clear that stem cell transplantation provides functional recovery via endogenous repair enhancement from multiple ways. This is important to maximize the effect of stem cell therapy after stroke, although it is still undetermined which repair mechanism is mostly contributed. | |||||
書誌情報 |
Neurologia medico-chirurgica 巻 55, 号 2, p. 107-112, 発行日 2015-02-15 |
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出版者 | ||||||
出版者 | 日本脳神経外科学会 | |||||
出版者別言語 | ||||||
Japan Neurosurgical Society | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04708105 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13498029 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2176/nmc.ra.2014-0271 | |||||
権利 | ||||||
権利情報 | c 2015 by The Japan Neurosurgical Society | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Neurologia medico-chirurgica, 55(2), pp.107-112; 2015 |