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Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts
http://hdl.handle.net/10069/35781
http://hdl.handle.net/10069/357814335147e-f144-4ead-b62b-502762695480
名前 / ファイル | ライセンス | アクション |
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JCMM19_1805.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-08-18 | |||||
タイトル | ||||||
タイトル | Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cardiosphere-derived cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dilated cardiomyopathy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dogs | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stem cell therapy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hensley, Michael Taylor
× Hensley, Michael Taylor× de, Andrade James× Keene, Bruce× Meurs, Kathryn× Tang, Junnan× Wang, Zegen× Caranasos, Thomas G.× Piedrahita, Jorge× Li, Tao-Sheng× Cheng, Ke |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The regenerative potential of cardiosphere-derived cells (CDCs) for ischaemic heart disease has been demonstrated in mice, rats, pigs and a recently completed clinical trial. The regenerative potential of CDCs from dog hearts has yet to be tested. Here, we show that canine CDCs can be produced from adult dog hearts. These cells display similar phenotypes in comparison to previously studied CDCs derived from rodents and human beings. Canine CDCs can differentiate into cardiomyocytes, smooth muscle cells and endothelial cells in vitro. In addition, conditioned media from canine CDCs promote angiogenesis but inhibit cardiomyocyte death. In a doxorubicin-induced mouse model of dilated cardiomyopathy (DCM), intravenous infusion of canine CDCs improves cardiac function and decreases cardiac fibrosis. Histology revealed that injected canine CDCs engraft in the mouse heart and increase capillary density. Out study demonstrates the regenerative potential of canine CDCs in a mouse model of DCM. | |||||
書誌情報 |
Journal of Cellular and Molecular Medicine 巻 19, 号 8, p. 1805-1813, 発行日 2015-08 |
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出版者 | ||||||
出版者 | Wiley-Blackwell | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15821838 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/jcmm.12585 | |||||
権利 | ||||||
権利情報 | c 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. | |||||
権利 | ||||||
権利情報 | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Cellular and Molecular Medicine, 19(8), pp.1805-1813; 2015 |