The isomaltulose based liquid formula (MHN-01), suppresses postprandial plasma glucose and insulin levels in healthy persons and patients with impaired glucose tolerance (IGT) or type 2 diabetes. MHN-01 intake as a part of breakfast also suppresses glucose and insulin levels after lunch, suggesting second meal effect. The objective of this study was to investigate the effects of nutritional counseling and long-term (24 weeks) MHN-01 ingestion on biomarkers of metabolic syndrome. Forty-one subjects with criteria of metabolic syndrome participated in this study composed with the control period (0-12 week) followed by nutritional counseling and the experimental period (12-36 week) followed by 200 kcal (837 kJ) of MHN-01 or dextrin-based standard balanced liquid formula (SBF) loading as a part of breakfast. In 16 of 41 subjects became to out of criteria for liquid formula loading study during control period (unqualified group). In the unqualified group, several biomarkers were improved. In experimental period, serum HbA1c levels significantly increased in SBF group (n = 12) but did not change in MHN-01 group (n = 10). Thus, intake of 837 kJ MHN- 01 as a part of breakfast may be effective for suppression of deteriorating glucose metabolism in metabolic syndrome.
雑誌名
Journal of Clinical Biochemistry and Nutrition
巻
57
号
2
ページ
140 - 144
発行年
2015-09-01
出版者
日本酸化ストレス学会
出版者別言語
Society for Free Radical Research Japan
ISSN
09120009
EISSN
18805086
DOI
10.3164/jcbn.14-132
権利
c 2015 JCBN
著者版フラグ
publisher
引用
Journal of Clinical Biochemistry and Nutrition, 57(2), pp.140-144; 2015
Effect of nutritional counseling and long term isomaltulose based liquid formula (MHN-01) intake on metabolic syndrome
JCBN57_140.pdf
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