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Clinical Significance of Autoantibodies in Primary Biliary Cirrhosis
http://hdl.handle.net/10069/35058
http://hdl.handle.net/10069/350587911e487-5166-43c7-826a-f84bda2529f5
名前 / ファイル | ライセンス | アクション |
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SLD34_334.pdf (280.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-09-01 | |||||
タイトル | ||||||
タイトル | Clinical Significance of Autoantibodies in Primary Biliary Cirrhosis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-gp210 antibodies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anticentromere antibodies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antimitochondrial antibodies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antinuclear antibodies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | primary biliary cirrhosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nakamura, Minoru
× Nakamura, Minoru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Antimitochondrial, anti-gp210, anti-sp100, and anticentromere antibodies are specifically detected in primary biliary cirrhosis (PBC). In clinical practice, they are useful for the diagnosis of PBC or for evaluating disease severity, clinical phenotype, and long-term outcome. In the typical or classical form of PBC which shows slow progressive loss of small bile ducts with a parallel increase in liver fibrosis, anti-gp210 antibodies are a strong risk factor for progression to jaundice and hepatic failure, whereas the presence of anticentromere antibodies is a risk factor for progression to cirrhosis and portal hypertension. Of note, the autoimmune repertoire, which is established during the early stage of the disease process, can influence the clinical phenotype and the long-term prognosis of PBC. Because the natural course of PBC is being altered by treatment with ursodeoxycholic acid, the clinical significance of these PBC-specific autoantibodies awaits re-evaluation in various ethnicities. | |||||
書誌情報 |
Seminars in Liver Disease 巻 34, 号 3, p. 334-340, 発行日 2014-08 |
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出版者 | ||||||
出版者 | Thieme Medical Publishers | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02728087 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10988971 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1055/s-0034-1383732 | |||||
権利 | ||||||
権利情報 | c 2014 by Thieme Medical Publishers, Inc. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Seminars in Liver Disease, 34(3), pp.334-340; 2014 |