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Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma
http://hdl.handle.net/10069/34054
http://hdl.handle.net/10069/3405403c1b160-5360-4cfc-b4eb-02dd69df77c5
名前 / ファイル | ライセンス | アクション |
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MarDru11_4267.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-01-15 | |||||
タイトル | ||||||
タイトル | Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fucoidan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lung metastasis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nanoparticle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osteosarcoma | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kimura, Ryuichiro
× Kimura, Ryuichiro× Rokkaku, Takayoshi× Takeda, Shinji× Senba, Masachika× Mori, Naoki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan induced apoptosis of an osteosarcoma cell line more efficiently than native fucoidan. The more potent effects of nanoparticle fucoidan, relative to native fucoidan, were confirmed in vivo using a xenograft osteosarcoma model. Caco-2 cell transport studies showed that permeation of nanoparticle fucoidan was higher than native fucoidan. The higher bioactivity and superior bioavailability of nanoparticle fucoidan could potentially be utilized to develop novel therapies for osteosarcoma. | |||||
書誌情報 |
Marine Drugs 巻 11, 号 11, p. 4267-4278, 発行日 2013-10-30 |
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出版者 | ||||||
出版者 | Multidisciplinary Digital Publishing Institute (MDPI) | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16603397 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/md11114267 | |||||
権利 | ||||||
権利情報 | © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Marine Drugs, 11(11), pp.4267-4278; 2013 |