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Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae
http://hdl.handle.net/10069/40219
http://hdl.handle.net/10069/402191d429588-9f38-4e3e-8a5e-d1b20d95db77
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYK1258_Uchida.pdf (2.3 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-08-25 | |||||
| タイトル | ||||||
| タイトル | Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bone quality | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bone cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Parathyroid hormone | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Implant | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
内田, 悠介
× 内田, 悠介 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 116853 | |||||
| 姓名 | Uchida, Yusuke | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Intermittent injection of parathyroid hormone (PTH) is used to treat osteoporosis. The concept of bone quality was updated 20 years ago; however, these updates have not been adopted in implant dentistry. This study aimed to investigate the effects of intermittent administration of PTH on bone quality around implants in rat tibiae. Methods: Grade IV-titanium-threaded implants that were 3.5 mm long and 2.0 mm wide were placed in a randomly selected side of the proximal tibiae of 12-week-old female Wistar rats. Three weeks after implant placement, the rats were randomly divided into PTH-administration and saline-injection groups (PTH and VC, respectively; n = 7 per group). Micro-computed tomographical, histomorphometric, and immunohistochemical analyses were performed to evaluate bone quality and quantity surrounding the implants. Results: PTH significantly increased bone volume and bone mineral density in bones not associated with the implants as compared to these values in the VC group. PTH significantly increased bone area and the amount of collagen within the total inside areas of all implant threads compared to that observed in VC. Moreover, PTH significantly increased the number of osteoblasts, osteocytes, and osteoclasts in the total inside and/or outside areas of all implant threads and altered the ratio of type I and III collagen to total collagen fibers. Conclusions: Within the limitations of this study, intermittent administration of PTH improved both bone quantity and bone quality based on the types and numbers of bone cells and the types of collagen fibers surrounding implants placed into rat tibiae. |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1258号 学位授与年月日:令和2年6月3日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Author: Yusuke Uchida, Shinichiro Kuroshima, Yusuke Uto, Riho Kanai, Maaya Inoue, Masayoshi Suzue, Takashi Sawase | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Journal of Oral Biosciences, 62(2), pp.139-146; 2020 | |||||
| 書誌情報 |
Journal of Oral Biosciences 巻 62, 号 2, p. 139-146, 発行日 2020-06-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13490079 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.job.2020.03.001 | |||||
| 権利 | ||||||
| 権利情報 | c 2020 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他のタイトル | ||||||
| その他のタイトル | PTHの間歇的投与がラット脛骨に埋入されたインプラント周囲の骨量と骨質に与える影響 | |||||
| 出版者 | ||||||
| 出版者 | 歯科基礎医学会 | |||||
| 関係URI | ||||||
| 識別子タイプ | HDL | |||||
| 関連識別子 | http://hdl.handle.net/10069/40085 | |||||
| 学位名 | ||||||
| 学位名 | 博士(歯学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17301 | |||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-06-03 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲医歯薬第1258号 | |||||
| 学位の種類 | ||||||
| 値 | 課程博士 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nagasaki University (長崎大学), 博士(歯学) (2020-06-03) | |||||
