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Clinical Significance of Microvessel Count in Patients with Metastatic Liver Cancer Originating from Colorectal Carcinoma.
http://hdl.handle.net/10069/23727
http://hdl.handle.net/10069/2372745859d2c-729b-4c92-9b04-6c510eae2fda
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AnnSurgOncol16_2130.pdf (502.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-09-01 | |||||
| タイトル | ||||||
| タイトル | Clinical Significance of Microvessel Count in Patients with Metastatic Liver Cancer Originating from Colorectal Carcinoma. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Metastatic liver carcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Microvessel count | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CD34 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | colorectal cancer Prognosis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Nanashima, Atsushi
× Nanashima, Atsushi× Shibata, Kenichirou× Nakayama, Toshiyuki× Tobinaga, Syuuichi× Araki, Masato× Kunizaki, Masaki× Takeshita, Hiroaki× Hidaka, Shigekazu× Sawai, Terumitsu× Nagayasu, Takeshi× Yasutake, Toru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: Microvessel count (MVC) has been correlated with patient prognosis in hepatocellular carcinoma. We investigated whether MVC assessed by staining with CD34 antibody was associated with disease-free and overall survival in patients with metastatic liver cancer (MLC). METHODS: We examined relationships between MVC and clinicopathologic factors or postoperative outcomes in 139 MLC patients who underwent hepatectomy between 1990 and 2006. CD34 expression was analyzed by the immunohistochemical method. RESULTS: MVC was associated with fibrous pseudocapsular formation on histological examination. By means of the modern Japanese classification of liver metastasis, poorer survival was associated with higher score, poorly differentiated adenocarcinoma, higher preoperative carcinoembryonic antigen (CEA) level, fibrous pseudocapsular formation, and smaller surgical margin. Shorter disease-free survival was associated with higher score when the Japanese classification of liver metastasis was used, multiple or bilobar tumor, regional lymph node metastasis in primary colon carcinoma, preoperative CEA level, fibrous pseudocapsular formation, and smaller surgical margin (<5 mm). Higher MVC (>/=406/mm(2)) was associated with decreased disease-free and overall survival by univariate analysis (P = .034 and P = .021, respectively), and higher MVC represented an independently poor prognostic factor in overall survival by Cox multivariate analysis (risk ratio, 2.71; P = .023) in addition to histological differentiation. CONCLUSIONS: Tumor MVC seems to be a useful prognostic marker of MLC patient survival. | |||||
| 書誌情報 |
Annals of surgical oncology 巻 16, 号 8, p. 2130-2137, 発行日 2009-08 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 10689265 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 15344681 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11016573 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 19495885 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1245/s10434-009-0459-8 | |||||
| 権利 | ||||||
| 権利情報 | c Society of Surgical Oncology 2009 | |||||
| 権利 | ||||||
| 権利情報 | The original publication is available at www.springerlink.com | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Annals of Surgical Oncology, 16(8), pp.2130-2137; 2009 | |||||
