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Random, top-down, or bottom-up coexistence of parasites: malaria population dynamics in multi-parasitic settings
http://hdl.handle.net/10069/22214
http://hdl.handle.net/10069/22214bbcf1137-d266-4898-b69c-807e34d7ae2e
名前 / ファイル | ライセンス | アクション |
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Ecology90_2414.pdf (346.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-10-06 | |||||
タイトル | ||||||
タイトル | Random, top-down, or bottom-up coexistence of parasites: malaria population dynamics in multi-parasitic settings | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bed nets | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cross-immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Loop analysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Malaria time series | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Parasite interactions | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmodium falciparum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmodium vivax | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Population regulation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Chaves, Luis Fernando
× Chaves, Luis Fernando× Kaneko, Akira× Pascual, Mercedes |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Epidemiological models concerned with the control of malaria using interventions such as bed nets and vaccines increasingly incorporate realistic aspects of malaria biology. The increasing complexity of these models limits their ability to abstract ecological processes and to address questions on the regulation of population dynamics using time-series data, particularly in regards to interactions between different pathogens and the regulatory role of innate (bottom-up) and acquired (top-down) immunity. We use a theoretical framework to test hypotheses on the importance of population-level immunity and parasite abundance in regulating the population dynamics of malaria. We use qualitative loop analyses to examine the sign of the interaction between Plasmodium falciparum and P. vivax at the population level, and we discuss implications of this sign for the within-host regulation of parasites. Our analyses of monthly malaria time-series data from the island of Espirito Santo, Vanuatu (1983-1997), show that the dynamics of P. falciparum are not sensitive to P. vivax, whereas infections by the latter increase in response to those of the former. These results support a differential use of resources inside the hosts, a resource-consumer interaction between hosts and their immune system, and within-host regulation of parasites. Finally, our results emphasize the need to better understand factors regulating malaria dynamics before developing control strategies and call for the use of control strategies directed at the interruption of transmission, such as vector control and the use of bed nets. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Copyright by the Ecological Society of America | |||||
書誌情報 |
Ecology 巻 90, 号 9, p. 2414-2425, 発行日 2009-09 |
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出版者 | ||||||
出版者 | Ecological Society of America | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00129658 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11618736 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1890/08-1022.1 | |||||
権利 | ||||||
権利情報 | c 2009 by the Ecological Society of America. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Ecology, 90(9), pp.2414-2425; 2009 |