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Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation.
http://hdl.handle.net/10069/22591
http://hdl.handle.net/10069/2259186707dd5-7e5e-4ec4-ba19-d2ff3cf9348e
名前 / ファイル | ライセンス | アクション |
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MutRes_Suzuki.pdf (225.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-12-04 | |||||
タイトル | ||||||
タイトル | Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CHO | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chromosome aberration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA repair | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Genomic instability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ionizing radiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Non-homologous end-joining | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Suzuki, Keiji
× Suzuki, Keiji× Kodama, Seiji× Watanabe, Masami |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ionizing radiation induces delayed destabilization of the genome in the progenies of surviving cells. This phenomenon, which is called radiation-induced genomic instability, is manifested by delayed induction of radiation effects, such as cell death, chromosome aberration, and mutation in the progeny of cells surviving radiation exposure. Previously, there was a report showing that delayed cell death was absent in Ku80-deficient Chinese hamster ovary (CHO) cells, however, the mechanism of their defect has not been determined. We found that delayed induction of DNA double strand breaks and chromosomal breaks were intact in Ku80-deficient cells surviving X-irradiation, whereas there was no sign for the production of chromosome bridges between divided daughter cells. Moreover, delayed induction of dicentric chromosomes was significantly compromised in those cells compared to the wild-type CHO cells. Reintroduction of the human Ku86 gene complimented the defective DNA repair and recovered delayed induction of dicentric chromosomes and delayed cell death, indicating that defective Ku80-dependent dicentric induction was the cause of the absence of delayed cell death. Since DNA-PKcs-defective cells showed delayed phenotypes, Ku80-dependent illegitimate rejoining is involved in delayed impairment of the integrity of the genome in radiation-survived cells. | |||||
書誌情報 |
Mutation research 巻 683, 号 1-2, p. 29-34, 発行日 2010-01-05 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13861964 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-5107 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10747915 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19822159 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.mrfmmm.2009.10.003 | |||||
権利 | ||||||
権利情報 | Copyright c 2009 Elsevier B.V. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Mutation research, 683(1-2), pp.29-34; 2010 |