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Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis.
http://hdl.handle.net/10069/22660
http://hdl.handle.net/10069/22660816f9a79-c8e2-4081-a2fa-61a36241685d
名前 / ファイル | ライセンス | アクション |
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RheInt_Okazaki.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-12-25 | |||||
タイトル | ||||||
タイトル | Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Autoantibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Caspase-3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pulmonary fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Renal vascular damage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Systemic sclerosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Okazaki, Shihoko
× Okazaki, Shihoko× Ogawa, Fumihide× Iwata, Yohei× Hara, Toshihide× Muroi, Eiji× Komura, Kazuhiro× Takenaka, Motoi× Shimizu, Kazuhiro× Hasegawa, Minoru× Fujimoto, Manabu× Sato, Shinichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The objective of the study was to determine the presence or levels of antibodies (Abs) against caspase-3 and their clinical relevance in systemic sclerosis (SSc). Anti-caspase-3 Ab was examined by enzyme-linked immunosorbent assay and immunoblotting. IgG anti-caspase-3 Ab levels in SSc patients were higher than in normal controls. SSc patients positive for IgG anti-caspase-3 Ab had significantly longer disease duration, more frequent presence of decreased %VC and %DLco, and elevated levels of serum immunoglobulin and erythrocyte sedimentation rates. IgG anti-caspase-3 Ab levels correlated positively with serum IgG levels, renal vascular resistance, and serum levels of 8-isoprostane. Immunoblotting analysis confirmed the presence of anti-caspase-3 Ab in sera from SSc patients. Caspase-3 enzymatic activity was inhibited by IgG isolated from SSc sera containing IgG anti-caspase-3 Ab. These results suggest that autoantibody against caspase-3 is generated in SSc and that this Ab is related to the severity of pulmonary fibrosis, vascular damage, and inflammation. | |||||
書誌情報 |
Rheumatology international 巻 30, 号 7, p. 871-878, 発行日 2010-05 |
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出版者 | ||||||
出版者 | Springer Berlin | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01728172 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1437-160X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA0040456X | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19639321 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00296-009-1068-3 | |||||
権利 | ||||||
権利情報 | c Springer-Verlag 2009 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Rheumatology international, 30(7), pp.871-878; 2010 |