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Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetes.
http://hdl.handle.net/10069/22894
http://hdl.handle.net/10069/2289496fc0393-59c1-4c36-9942-94d2f2ee5583
名前 / ファイル | ライセンス | アクション |
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ANYAS1150_248.pdf (274.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-02-05 | |||||
タイトル | ||||||
タイトル | Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetes. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GAD | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IA-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ICA | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kawasaki, Eiji
× Kawasaki, Eiji× Kuriya, Genpei× Satoh, Tsuyoshi× Fujishima, Keiichiro× Moriuchi, Akie× Fukushima, Keiko× Ozaki, Masako× Abiru, Norio× Yamasaki, Hironori× Eguchi, Katsumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, we evaluated autoantibodies to IA-2 (IA-2As), glutamic acid decarboxylase 65 (GADAs), and islet cell antibodies (ICAs) in 233 patients with type 1 diabetes (M:F = 90:143, mean duration 4.0 +/- 6.7 yr) as a cross-sectional study. Of 233 patients with type 1 diabetes, IA-2A was detected in 58% of patients with duration within 2 weeks, 61% of patients with duration <1 yr, 41% of patients with diabetes for 1-3 yr, 29% for 4-9 yr, and 21% for >or=10 yr. These prevalences were similar to those of ICA, while the prevalence of GADA was not influenced by duration of diabetes with positivity of 63-74%. Thus, as the duration of diabetes became longer, the frequency of GADA(+)/IA-2A(-) patients increased and the frequency of GADA(+)/IA-2A(+) patients decreased. However, the frequency of GADA(-)/IA-2A(+) patients was not influenced by duration of diabetes. The prevalence of IA-2A was significantly higher in abrupt-onset group (68%, n= 79) compared to the slowly progressive group (23%, n= 22) in new-onset patients (P= 0.0001). However, there was no difference in the IA-2A frequency between these two groups (abrupt-onset 26%, n= 53 vs. slowly progressive 24%, n= 21) in patients with long-standing disease, suggesting that IA-2A positivity might persist in patients with slowly progressive type 1 diabetes. These results emphasize the heterogeneity of humoral autoimmunity to protein tyrosine phosphatase-like molecules, but not to GAD, in patients with type 1 diabetes. | |||||
書誌情報 |
Annals of the New York Academy of Sciences 巻 1150, p. 248-251, 発行日 2008-12 |
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出版者 | ||||||
出版者 | New York Academy of Sciences | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00778923 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1749-6632 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00051776 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19120305 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1196/annals.1447.027 | |||||
権利 | ||||||
権利情報 | c 2008 The New York Academy of Sciences | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Annals of the New York Academy of Sciences, 1150, pp.248-251; 2008 |