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The Effects of γ-tocopherol Administration on Pretibial Edema in Young Women with Premenstrual Syndrome
http://hdl.handle.net/10069/21499
http://hdl.handle.net/10069/2149960166598-e26c-4077-918c-b31e23d0c7ed
名前 / ファイル | ライセンス | アクション |
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acta_53_3_59.pdf (444.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2009-04-07 | |||||
タイトル | ||||||
タイトル | The Effects of γ-tocopherol Administration on Pretibial Edema in Young Women with Premenstrual Syndrome | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | γ-tocopherol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | γ-CEHC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Premenstrual syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Edema | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HPLC | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kato, Shigeko
× Kato, Shigeko× Shiraishi, Keiko× Koshida, Sayo× Mune, Masatoshi× Omagari, Katsuhisa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Gamma-tocopherol is largely metabolized to 2,7,8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (γ-CEHC), which has natriuretic activity that is mediated via inhibition of 70 pS ATP-sensitive K+ channels in the thick ascending limb of the loop of Henle. However, the effects of γ-tocopherol administration on edema are unclear. To determine the effects of γ-tocopherol administration on pretibial edema, we measured urinary γ-CEHC concentration by high-performance liquid chromatography with electrochemical detection (HPLC-ECD) after administration of γ-tocopherol. Twenty young women who had a history of pretibial edema due to premenstrual syndrome were randomly divided into two groups. The γ-tocopherol group received 4 "γ-tocopherol capsules" (each containing 100mg of γ-tocopherol), and the control group received 4 "placebo capsules" (each containing 250mg of soybean oil) per day for 7 days. Urinary sodium and potassium secretion and urine volume did not increase after cessation of γ-tocopherol administration, yet the degree of pretibial edema improved in all participants in the γ-tocopherol group. The serum γ-tocopherol concentration significantly increased in the γ-tocopherol group. Urinary excretion of γ-CEHC significantly increased after γ-tocopherol administration. Our results suggest that orally administered γ-tocopherol on renal sodium handling is not apparent, but γ-tocopherol is a precursor of prolonged natriuresis of γ-CEHC and may be effective for edema. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 53, 号 3, p. 59-64, 発行日 2009-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/53.59 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 53(3), pp.59-64 ; 2009 |